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This study identifies a noncanonical TNL immune hub in Brassica napus that operates through separable recognition and signaling modules for clubroot resistance, independent of EDS1/NDR1.

This study characterizes the lipidomic profile of urine extracellular vesicles in male alcohol use disorder patients, identifying FA 22:0 as a potential biomarker linked to inflammation and metabolic dysfunction.

This study shows astrocytes process and propagate α-synuclein aggregates via lysosomal protease Cathepsin D, promoting Lewy neurite-like aggregation in neurons.

This study shows that blocking CXCR4 improves lung and cardiac outcomes in early COPD using both human samples and mouse models.

This study develops deep-learning models to detect melanocytic atypia from H&E slides using complementary IHC stains, achieving high AUROC and AUPRC scores despite limited paired tissue data.

This study uses machine learning to analyze speech acts in late-talking and typically developing preschoolers, finding differences in speech act production and comprehension.

This paper develops a high-throughput screening method for anti-NNV drugs using a target-driven activatable aptamer probe, achieving rapid, sensitive, and specific detection of anti-NNV compounds.

This study develops PDE3A2-modRNA to restore nuclear cAMP microdomain regulation, reversing pathological cardiac hypertrophy in a mouse model.

This study shows that ATG4D deficiency in mice causes late-onset cardiomyopathy and stress-induced heart failure, and ATG4D repression is linked to human cardiac remodeling.

This study shows that oral exposure to infected tissues can induce ASE-like lesions in juvenile Chinook Salmon, suggesting an infectious cause for the disease.

This study tests if deleting Cd248 in Postn+ myofibroblasts reduces cardiac fibrosis in pressure-overload cardiomyopathy, but finds no significant improvement in cardiac function or fibrosis.

This study shows that TLR4 promotes liver fibrosis in MASLD through mechanisms not involving hepatocytes or inflammatory cells.

FUSION is a web-based tool that integrates spatial -omics data with histology to analyze tissue states and identify spatial linkages between molecular and histopathologic features.

This study identifies N-acetyl-phenylalanine (NAPA) as a metabolite that promotes hepatic steatosis in MASLD by disrupting ER-mitochondria calcium coupling and mitochondrial lipid oxidation.

This study shows that deleting Lzp in mice reduces plasma lipids and atherosclerosis by lowering ApoB-containing lipoproteins.

This study compares QuPath and HALO for analyzing prostate cancer tumor microenvironment using multiplex immunofluorescence data, finding high concordance and demonstrating QuPath's flexibility.

This study investigates RD-induced melanocyte loss in guinea pigs, finding basement membrane disorganization and MMP2 activity contribute to melanocyte detachment and depigmentation.

This study shows that overexpressing ERG in endothelial cells prevents vascular regression and neuronal damage in OIR models, suggesting ERG as a potential therapeutic target for retinopathies.

This study shows that Ritlecitinib reduces neointima formation and enhances endothelial recovery after vascular injury by modulating JAK3 signaling and VEGF-A/TSP-1 pathways.

This study identifies sex-specific mitochondrial dysfunction in endothelial cells of diabetic PAD patients, showing that MitoQ improves vascular function in females.