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This study describes the cardiac phenotype of DE50-MD dogs, a dystrophin-deficient model of DMD, showing early cardiac changes similar to human DMD patients.

This paper introduces a protocol for 3D multiplexed immunohistochemistry using Opal-TSA conjugated fluorescent dyes to enhance imaging of pulmonary TB lesions in mouse tissues.

This study shows that inhibiting MTAP reduces kidney injury markers and improves renal histology in AKI mouse models and links MTAP expression to kidney injury in human single-cell RNA sequencing data.

This study uses a Complex Adaptive Systems framework to analyze health outcomes of 19th-century migrants to South Australia by integrating bioarchaeological and historical data.

This paper develops a RPA-DETECTR assay for rapid, sensitive, and specific detection of Foc TR4, outperforming PCR and qPCR in speed and sensitivity.

This study identifies key functional regions of GGCX and their interactions with FIX using AlphaFold 3 and simulations, revealing residues critical for carboxylation and vitamin K epoxidation.

This study shows that pathological tau isoforms in retinal ganglion cells (RGCs) are linked to RGC degeneration in Alzheimer's disease, with significant correlations between tau levels and disease severity.

This study characterizes SVNV proteins through sequence analysis of field strains and compares their localization in plant and insect cells.

This study shows that higher parasite burden in vertebrate hosts leads to shorter extrinsic incubation periods in mosquitoes, but not increased transmissible stages.

This study shows that a diet enriched with deuterium-reinforced polyunsaturated fatty acids (D-PUFA) prevents muscle atrophy and weakness in STZ-induced diabetic mice.

The paper reports that male mice undergoing general anesthesia with fentanyl, midazolam, and medetomidine develop obstructive uropathy, while using xylazine instead prevents this complication.

This study re-establishes the golden Syrian hamster as an MCF model and identifies T cells and macrophages as key infected cells, with broader viral tropism including endothelial cells and epithelia.

This study shows that loss of LCAD protects against acute kidney injury by reducing oxidative stress and enhancing peroxisomal fatty acid oxidation.

This study shows that disrupting TGFβ signaling in adult mice makes the aorta susceptible to hypertension-induced dissection, even from short-term blood pressure increases.

This study investigates the limited effectiveness of enzyme replacement therapy (ERT) in advanced Fabry disease cardiomyopathy, identifying myocardial fibrosis, inflammation, and reduced mannose-6-phosphate receptors as barriers to therapy.

This study uses a K18-hACE2 mouse model to show SARS-CoV-2 infects neurons in the brain without damaging blood vessels, leading to limited neuroinflammation.

This study evaluates the anti-hyperglycemic effects of Nigella sativa and Cichorium intybus, and their combination, in alloxan-induced diabetic rabbits, showing significant reductions in blood glucose and improvements in hematological parameters.

This study examines the link between cephalothorax discoloration in Pandalus borealis shrimp and cadmium concentration, finding no significant correlation.

This study shows that an oro-nasal fistula in mice causes microbiome dysbiosis, which hinders healing, but delivering Lactococcus lactis subsp. cremoris promotes healing and restores microbial balance.

This study analyzes longitudinal electronic health records to identify comorbidity patterns influenced by COVID-19 and their biological mechanisms through protein-protein interaction networks.