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This paper develops a microphysiological system using hiPSC-derived neurons and cardiomyocytes to model sympathetic neuro-cardiac interactions and test drug effects.

This study shows that ovulation is essential for female sexual receptivity in medaka, and progesterone signaling in specific brain regions synchronizes sexual behavior with the ovulatory cycle.

The paper develops and applies transvaginal ovum retrieval techniques in scimitar horned oryx and roan antelope to support assisted reproductive technologies for conservation.

This study shows that Δ133p53 reduces CXCL10 levels in progeria and aged mice, linking it to anti-inflammatory effects.

This study shows that high PVC burden causes inflammation and fibrosis, leading to adverse cardiac remodeling and increased risk of heart failure and sudden cardiac death.

This paper develops a hybrid machine learning and musculoskeletal simulation framework to improve dynamics estimation from smartphone video during walking, achieving lower error rates than simulation-only or ML-only approaches.

The paper quantifies sex differences in steroid and neuropeptide levels across the zebrafish brain-pituitary-gonadal axis, revealing distinct patterns in hormone production between males and females.

The paper uses cryo-electron tomography to reveal the native structure of the human slit diaphragm, showing a fishnet-like lattice with 9 nm spacing, more compact than in mice or Drosophila.

This study shows that early post-injury changes in mouse respiration and motor activity can predict future pain-related outcomes after spinal cord injury.

This study shows that inactivating DHHC7 in mouse liver leads to obesity via a Prg4-GPR146 axis, affecting adipose lipolysis and fat accumulation.

The paper shows cardiac-sympathetic outflow predicts action restraint during a task, with effects modulated by reward and loss conditions and participant success.

This study identifies distinct post-translational modifications in fibrinaloid microclots across Pre-COVID-19 POTS, Long COVID, and LC-POTS, revealing disease-specific molecular pathways.

This study shows that knocking out LRRC8A in vascular smooth muscle cells reduces superoxide influx, inflammation, senescence, and atherosclerosis.

This study examines metabolic and physiological responses to exercise across four fitness levels in male cyclists, finding hierarchical patterns in performance and metabolic parameters.

This study shows that the claudin-1 inhibitor PDS-0330 reduces urinary albumin excretion and attenuates Src/Akt/mTOR signaling in podocytes of diabetic mice.

This study shows that bacterial metabolism of tryptophan to indole causes toxicity in C. elegans, which is reduced by sugar supplementation.

This study shows that dietary fat affects mitochondrial and lipid droplet lipid profiles in skeletal muscle, with specific lipid classes linked to metabolic health and insulin resistance.

The paper shows that lowering insulin levels in mice prevents reproductive aging and diet-induced ovarian dysfunction, linking hyperinsulinemia to subfertility.

This study shows that LRRK2-G2019S mutation in microglia increases nuclear ASC speck formation, indicating a primed inflammasome state linked to chronic neuroinflammation in Parkinson's disease.

The paper investigates how heart rate synchrony (IPS) is influenced by proximity, social familiarity, and acoustic environment in naturalistic social settings.