Discover, rate, and discuss biology preprints.

This study develops an electroejaculation protocol to assess seasonal semen variation in rock hyraxes, finding higher sperm quality during peak mating season and increased abnormalities post-peak.

The paper identifies CEND1 as a regulator of activity-dependent glucose metabolism by facilitating mitochondrial ATP channeling to hexokinase I.

This study shows that PP2A B55 binds to activated AT2R and is essential for AT2R signaling, natriuresis, and intracellular trafficking in renal proximal tubule cells.

This study identifies a metabolic myopathy in HFpEF through multiomics analysis of skeletal muscle, revealing mitochondrial dysfunction and altered amino acid metabolism.

This study shows that TERT expression in adipose tissue reduces inflammation and improves metabolism in obesity by altering macrophage states and stem cell-macrophage communication.

This study shows that disrupting non-canonical autophagy (LANDO) impairs endothelial and cardiac function by disrupting VEGFR2 recycling and Hb- expression.

This study shows GSNOR deletion protects male cardiac function with age but may worsen female cardiac function by removing an age-related SNO imbalance.

This study investigates the roles of HCN1 and HCN4 in synchronizing sinoatrial pacemaker cells, finding HCN1 is essential for fast synchronisation while HCN4 is not.

The paper identifies an estrogen-responsive paracrine pathway in the gut that increases sensitivity in females by enhancing communication between enteroendocrine cells and sensory nerves.

This paper develops a respirometry methodology to measure metabolic parameters in Delta Smelt, overcoming previous challenges by incorporating an air pocket to accommodate their physotomous behavior.

This study shows that left and right vagal oxytocin signaling differentially control feeding and socioemotional behaviors via hypothalamic oxytocin neurons in mice.

This study identifies NaV1.3 as a druggable target in adult lymphatic muscle that can restore contractility in aging and radiation injury.

The paper identifies the transaminase-omega-amidase pathway as a redox-sensitive metabolic switch in endothelial glutamine metabolism, showing that NIT2 oxidation inhibits its activity and affects angiogenesis.

This study shows that a CACNA1D variant causes electrophysiological abnormalities in hiPSC-CMs, which are reversed by AAV6-Cav1.3-C-terminus gene therapy.

This study shows that pulsatile blood flow, not reduced flow, impairs hippocampal mitochondrial respiration in aging rats after transverse aortic constriction.

This study shows that Dance Movement Therapy improves vagally-mediated heart rate variability in older adults, suggesting benefits for physical and mental health through enhanced social interaction and well-being.

This study shows that reducing METTL3 is necessary for decidualization in humans and mice by maintaining HAND2 expression through m6A modification.

This study investigates how exercise induces molecular and signaling changes in the spinal cord using multi-omic approaches, revealing coordinated neuron-glia communication as key to spinal cord adaptation.

This study examines how sex and reproductive condition influence thermal acclimation in salamanders, finding that gravid females show distinct metabolic responses compared to males and non-gravid females.

This study shows that YME1L-dependent degradation of MICU1 regulates mitochondrial Ca2+ uptake in response to nutrient changes, linking metabolic signals to mitochondrial function.