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High latitude, high tolerance: Northern juvenile Chinook salmon exhibit substantial thermal plasticity and acute heat tolerance

This study shows that northern juvenile Chinook salmon have high thermal tolerance and plasticity, with warm acclimation improving heat tolerance and cardiac function.

Failed allogeneic corneal lenticules show fibrosis and identity loss without dominant T cell rejection

The paper examines failed allogeneic corneal lenticules, finding fibrosis and loss of corneal identity without dominant T cell rejection, and explores treatment strategies.

HiSpoT: a novel one-tube dual-barcode PCR method for NGS spoligotyping amplicon library preparation in Mycobacterium tuberculosis complex

HiSpoT is a PCR-based method for preparing NGS libraries for spoligotyping MTBC isolates, offering high-throughput, low-cost, and accurate strain typing with open-source tools for analysis.

Short-read whole-genome sequencing identifies the Tg(Tal1-cre/ERT)42-056Jrg transgene insertion site on mouse chromosome 4

RPI-Zero: Zero-shot RNA-Protein Interaction Prediction

RPI-Zero predicts RNA-protein interactions without prior data by using a sequence-only model trained on a large benchmark of CLIP experiments.

A timeline for evolution of metabolism in early microbes

The paper uses machine learning and phylogenomics to date 14 metabolic forms and 6 traits in early microbes, finding three waves of metabolic evolution starting >3.4 Ga.

LCN2+ Astrocytes Mark a Pro-inflammatory Astrocyte State Associated with Secondary Brain Injury After Cerebral Venous Thrombosis

Highly prevalent cargo genes of F plasmids harbored in pathogenic Escherichia coli

The paper identifies two groups of previously uncharacterized cargo genes in F plasmids of pathogenic E. coli, potentially contributing to virulence and antimicrobial targets.

Individualized AI-driven Neuromodulation Selectively Enhances and Reorganizes Human Tongue Sensorimotor Networks.

This paper introduces an AI-driven neuromodulation platform that enhances and reorganizes human tongue sensorimotor networks by targeting individual network architecture.

Live attenuated YFV-17D vaccine induces robust B and T cell immunity in vaccine-draining lymph nodes

This study examines immune dynamics in lymph nodes after YFV-17D vaccination, identifying robust B and T cell responses and a conserved germinal center program across different vaccines.

TRPP Ion Channels Function in the π-Conformation Rather Than the α-Conformation

This study uses molecular dynamics simulations to show that the π-conformation of PKD2 supports ion conduction, challenging the previous model that the α-conformation is the conductive state.

HIV-1 Vpu complements HLA-A downregulation by Nef and impairs TCR-mediated recognition of HIV-infected cells through distinct mechanisms

This study shows HIV-1 Vpu reduces HLA-A expression and impairs TCR recognition, acting independently of Nef and requiring BST2/tetherin.

Feedback Valence, Prediction Error, and the Limits of Computational Attribution in Symptom-Related EEG

The paper examines feedback valence and prediction error in EEG responses related to anxiety, finding a symptom-linked association but limited computational specificity.

Cytomegalovirus Infection in Human Cortical Organoids Induces Unique Developmental and Viral Substates

This study uses single-cell RNA sequencing to analyze HCMV infection in cortical organoids, identifying viral sub-states and cell type changes.

Provenance-aware handling of identical dengue genome records alters inferred envelope-protein variation in Bangladesh DENV-3

The paper evaluates how handling identical dengue genome records affects inferred envelope-protein variation in a Bangladesh DENV-3 dataset, showing that exclusion strategies can lead to loss of variation.

Genome-wide chromatin accessibility during early embryogenesis in a generalist cichlid fish

This study maps genome-wide chromatin accessibility in A. calliptera embryos across three stages, revealing dynamic changes in regulatory elements and transcription factor activity during early development.

WheatPanRef: a unified linear pan-reference genome for wheat genomics

WheatPanRef provides a unified linear pan-reference genome for wheat, improving read alignment and enabling integration of genomic resources across diverse accessions.

Functional Assessment and Extended Culture of Human Pediatric Cardiac Tissue Slices for Preclinical Testing

This study develops a method to culture human pediatric cardiac tissue slices for extended periods, enabling functional and pharmacological testing of cardiac physiology.

Response to azacitidine and the TIM-3 inhibitor, sabatolimab, in MDS and CMML is associated with distinct immune and antigen-presentation states

This study identifies immune and antigen-presentation states associated with response to azacitidine and sabatolimab in MDS and CMML using single-cell RNA sequencing.

Common attentional mechanisms, but distinct computational dynamics, across Statistical and Reward Learning

This study compares statistical and reward learning, finding shared attentional mechanisms but distinct computational dynamics in neural representations and learning rates.