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A novel 5-HT2A receptor-linked signalling pathway involving NAADP-mediated lysosomal Ca2+ release

This paper discovers a novel 5-HT2A receptor-linked signaling pathway involving NAADP-mediated lysosomal Ca2+ release, showing reduced hallucinogenic and neuroplastic effects upon genetic ablation of the pathway in mice.

Spinal Noradrenergic Overdrive Promotes Reversible Motor Unit Aging and Sarcopenia

This study shows that aging increases spinal noradrenergic activity, leading to motor neuron hyperexcitability and sarcopenia, which can be reversed by suppressing noradrenergic signaling.

The self-renewing lymphoid-biased hematopoietic stem cells support long-term lymphopoiesis in mice

The paper identifies a self-renewing lymphoid-biased HSC subset in mice that maintains lymphopoiesis during aging and may serve as a backup source for immune function.

Integrated transcriptomic and epigenomic profiling of human cartilage reveals coordinated changes in fibronectin expression, splicing, and receptor signaling during osteoarthritis progression

This study profiles human cartilage across OA grades, revealing changes in fibronectin expression, splicing, and receptor signaling during disease progression.

ARCADE disentangles cell abundance from continuous transcriptional state in spatial transcriptomics

ARCADE improves spatial transcriptomic analysis by separating cell abundance from transcriptional state, enhancing deconvolution accuracy and interpretability in complex tissues.

Long-term biodiversity responses to anthropogenic change are spatially and taxonomically heterogeneous across coastal wetlands

The paper examines long-term biodiversity responses to human activity in coastal wetlands using sedimentary DNA and environmental data, finding context-dependent relationships between enrichment and biodiversity.

A domain-general basal ganglia mechanism for inhibitory control during language comprehension

This study shows that inhibitory control during language comprehension and motor inhibition share a domain-general mechanism involving the subthalamic nucleus.

Scalable Contact-Gated Stochastic Operators and Universal Reduction Laws for Macromolecular Protein Dynamics, Allostery, and Kinetics

This paper develops a scalable, thermodynamically reversible stochastic operator for macromolecular dynamics, showing universal reduction laws and improved performance over existing methods.

Aging reshapes cardiac extravascular leukocyte transcription through bidirectional remodeling during LPS-induced endotoxemia

This study shows aging causes bidirectional transcriptional changes in cardiac immune cells during LPS-induced endotoxemia, with shared mitochondrial remodeling and cell-type-specific functional shifts.

Adipocyte Kindlin-2 Coordinates an E-cadherin/β-catenin/IGFBP2 Endocrine Axis to Regulate Skin Regeneration and Diabetic Wound Healing

This study identifies adipocyte Kindlin-2 as a regulator of skin wound healing through an endocrine axis involving E-cadherin, β-catenin, and IGFBP2.

ssGSEA3.0: Feature-Level Bootstrap Resampling for Robust Assessment of Statistical Significance

ssGSEA3.0 improves statistical significance assessment in ssGSEA by using feature-level bootstrap resampling, enhancing detection power while maintaining calibration across weighting schemes.

Closed-loop acoustic stimulation promotes local slow oscillation train initiation and persistence in elderly adults

This study shows that closed-loop acoustic stimulation enhances rhythmic slow oscillation activity in elderly adults by increasing consecutive SOs and train length.

Defining nutrient dependencies of intestinal Klebsiella pneumoniae guides rational probiotic engineering

This study identifies nutrient dependencies of intestinal Klebsiella pneumoniae and develops a probiotic consortium to restrict its expansion.

Quantifying direct and indirect maternal effects on male vervets rank post-dispersal

This study examines how maternal characteristics affect male vervet monkeys' rank post-dispersal and finds limited long-term effects, with social behavior mediating some relationships.

Noise-referenced multi-shell diffusion-weighted imaging for regional cerebrospinal fluid thermometry

This paper develops a diffusion-weighted imaging method to estimate cerebrospinal fluid temperatures in different regions and finds ventricular temperatures are consistently higher than subarachnoid temperatures.

Norepinephrine inhibits Afferent activation of NTS Catecholamine Neurons in Mice

This study shows norepinephrine inhibits excitatory synaptic transmission from solitary tract afferents to NTS catecholamine neurons in mice, with a presynaptic mechanism involving alpha-adrenergic receptors.

A Preventive Effect of Exercise in a Mouse Model of Essential Tremor

This study shows that high-intensity interval training reduces tremor frequency in a mouse model of essential tremor, while resistance training and sedentary behavior do not.

A cotranslational role for selenocysteine in productive protein folding

This study shows that selenocysteine (Sec) plays a role in protein folding during biosynthesis, not just in mature proteins, by demonstrating that its incorporation affects dimer formation in SELENOM.

Seesaw configuration of the ODC-OAZ1-AZIN1 axis governs sensitivity to polyamine-targeting inhibitors of breast cancer cells

This study identifies a seesaw configuration of the ODC-OAZ1-AZIN1 axis that determines breast cancer cell sensitivity to polyamine-targeting inhibitors, offering a framework for personalized therapy.

Cognitive reserve depends on cortical neurochemistry to predict memory after partner-inflicted brain injury

The paper investigates how cognitive reserve interacts with neurochemical markers to predict memory outcomes after partner-inflicted brain injury in women.