Author

C. A. Dawson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

E. Crittenden· 5 shared N. R. Casewell· 5 shared K. E. Bartlett· 4 shared S. R. Hall· 4 shared J. M. Gutierrez· 3 shared L.-O. Albulescu· 3 shared R. A. Harrison· 3 shared J. Alsolaiss· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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5 shared papersPharmacology & Toxicology

E. Crittenden

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Dermonecrosis caused by spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib

K. E. Bartlett, S. R. Hall, S. A. Rasmussen, E. Crittenden, C. A. Dawson, L.-O. Albulescu, W. M. Laprade, R. A. Harrison, A. J. Saviola, C. M. Modahl, T. P. Jenkins, M. C. Wilkinson, J. M. Gutierrez, N. R. Casewell

This study identifies toxin synergism in spitting cobra venom causing dermonecrosis and shows that varespladib prevents tissue damage in mouse models.

bioRxiv · Jul 20, 2023Pharmacology & Toxicology

Machine-learning guided Venom Induced Dermonecrosis Analysis tooL: VIDAL

W. M. Laprade, K. E. Bartlett, C. R. Christensen, T. D. Kazandjian, R. N. Patel, E. Crittenden, C. A. Dawson, M. Mansourvar, D. S. Wolff, T. J. Fryer, A. H. Laustsen, N. R. Casewell, J. M. Gutierrez, S. R. Hall, T. P. Jenkins

VIDAL is a machine-learning tool that automatically analyzes dermonecrosis in mouse models to assess antivenom efficacy, offering an accurate and reproducible alternative to manual methods.

bioRxiv · May 21, 2023Pharmacology & Toxicology

Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms

S. R. Hall, S. A. Rasmussen, E. Crittenden, C. A. Dawson, K. E. Bartlett, A. P. Westhorpe, L.-O. Albulescu, J. Kool, J. M. Gutierrez, N. R. Casewell

The paper shows repurposed drugs and their combinations reduce cytotoxicity of snake venoms in cell and mouse models, offering potential new treatments for snakebite envenoming.

bioRxiv · May 20, 2022Pharmacology & Toxicology

Exploring the utility of recombinantly expressed snake venom serine protease toxins as immunogens for generating experimental snakebite antivenoms

N. Alomran, P. Blundell, J. Alsolaiss, E. Crittenden, S. Ainsworth, C. A. Dawson, R. J. Edge, S. R. Hall, R. A. Harrison, M. C. Wilkinson, S. K. Menzies, N. R. Casewell

This study evaluates recombinant snake venom serine protease toxins as immunogens to generate antivenoms that target specific venom-induced pathologies.

bioRxiv · May 7, 2022 · PreprintImmunology

A combination of two small molecule toxin inhibitors provides pancontinental preclinical efficacy against viper snakebite

L.-O. Albulescu, C. Xie, S. Ainsworth, J. Alsolaiss, E. Crittenden, C. A. Dawson, R. Softley, K. E. Bartlett, R. A. Harrison, J. Kool, N. R. Casewell

This study shows that a combination of two small molecule inhibitors effectively neutralizes viper venom in vitro and prevents lethality in vivo across multiple regions.

bioRxiv · May 13, 2020Pharmacology & Toxicology