A. Wagner

Gene swamping alters evolution during rangeexpansions in the protist Tetrahymena thermophila

This study tests the gene swamping hypothesis by showing sex accelerates local adaptation without gene flow but hinders it with gene flow in Tetrahymena thermophila during range expansions.

K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions

This study identifies potassium-dependent conformational changes in K2P2.1 channels that underlie C-type gating, revealing asymmetric order-disorder transitions in the selectivity filter and adjacent loops.

Natural selection has preserved and enhanced the phase-separation properties of FUS during 160 million years of mammalian evolution

The paper examines the evolutionary conservation of FUS's phase-separation properties, finding stabilizing and positive selection acting on its prion-like domain.

Genotype networks of 80 quantitative Arabidopsis thaliana phenotypes reveal phenotypic evolvability despite pervasive epistasis

The paper constructs genotype-phenotype maps for 80 Arabidopsis thaliana phenotypes using genome-wide association data, revealing that despite widespread epistasis, many phenotypes retain accessible evolutionary paths.

Gene expression noise can promote the fixation of beneficial mutations in fluctuating environments

The paper shows that gene expression noise can enhance the fixation of beneficial mutations in fluctuating environments by reducing population bottlenecks.

Metabolic and Epigenomic Regulation of Th17/Treg Balance by the Polyamine Pathway

The paper identifies the polyamine pathway as a regulator of Th17/Treg balance, showing its impact on inflammation and T cell phenotype.

Evolution under pH stress and high population densities leads to increased density-dependent fitness in the protist Tetrahymena thermophila

This study shows that under pH stress and high population densities, Tetrahymena thermophila genotypes evolve to converge in density-dependent fitness through changes in intrinsic growth rate or competitive ability.

CX3CL1 and CX3CR1 Expressing Tendon Cells - A novel Immune Cell Population in the Tendon Core

This study identifies CX3CL1+/CX3CR1+ cells in healthy tendons, suggesting they may have surveillance roles in tendon tissue.

Species-specific recognition of Sulfolobales mediated by UV inducible pili and S-layer glycosylation patterns

This study identifies species-specific regions in Sulfolobus pilin subunits and unique N-glycan patterns that mediate species-specific aggregation and DNA exchange.

Identifying dynamic, partially occupied residues using anomalous scattering

This study presents methods to detect dynamic, partially occupied protein conformations in crystals using anomalous scattering signals with low occupancy.

Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy

The paper predicts synthetic rescue mediators of resistance to targeted and immunotherapy using tumor transcriptomics and survival data from 10,000 TCGA patients, validating predictions through experimental screens.