Author

B. Alexander

Fox Chase Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1 Cell Biology· 1 Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. D. Ellington· 1 shared A. Ferrier· 1 shared A. Glasgow· 1 shared A. House· 1 shared A. Kashina· 1 shared A. Mellon· 1 shared Adam C. Martyn· 1 shared Adèle C. GreeniD· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperBioengineering

A. D. Ellington

Author profile →

5 papers

Recent·Most cited

BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance

Ksenija Nesic, John J. Krais, Yifan Wang, Cassandra J. Vandenberg, Pooja Patel, Kathy Qi Cai, Tanya Todorova Kwan, Elizabeth Lieschke, Gwo‐Yaw Ho, Holly E. Barker, Justin Bedő, Silvia Casadei, Andrew Farrell, Marc R. Radke, Kristy Shield‐Artin, , Lyndal S. Edwards

This study identifies secondary splice-site mutations in BRCA1 that drive exon skipping and PARP inhibitor resistance in ovarian and breast cancer.

Molecular Cancer · Aug 5, 2024Peer-reviewedGenetic & Genomic Medicine

Deep learning redesign of PETase for practical PET degrading applications

H. Lu, D. J. Diaz, N. J. Czarnecki, C. J. Zhu, W. Kim, D. J. Acosta, B. Alexander, R. Shroff, H. Cole, Y. J. Zhang, N. Lynd, A. D. Ellington, H. S. Alper

This paper uses deep learning to redesign PETase, creating a highly active and stable enzyme for efficient PET degradation and industrial recycling.

bioRxiv · Oct 10, 2021 · PreprintBioengineering

Curvature of the retroviral capsid assembly is modulated by a molecular switch

T. Thame, B. Alexander, X. Qiao, J. Jeon, R. Weed, K. Janicki, B. Hu, P. L. Gorkov, I. Hung, Z. Gan, J. R. Perilla, B. Chen

The paper identifies key residues that enable a molecular switch in retroviral capsid proteins, allowing curvature changes during capsid assembly.

bioRxiv · Dec 26, 2020Biophysics

A new mechanism of fibronectin fibril assembly revealed by live imaging and super-resolution microscopy.

D. Tomer, C. Arriagada, S. Munshi, B. Alexander, B. French, P. Vedula, V. Caorsi, A. House, M. Guvendiren, A. Kashina, J. Schwarzbauer, S. Astrof

This study reveals that Fn1 fibrils are composed of nanodomains rather than continuous fibers, using live imaging and SMLM to challenge the traditional view.

bioRxiv · Sep 9, 2020Cell Biology

Blood cells of adult Drosophila do not expand, but control survival after bacterial infection by induction of Drosocin around their reservoir at the respiratory epithelia

P. Sanchez Bosch, K. Makhijani, L. Herboso, K. S. Gold, R. Baginsky, K. J. Woodcock, B. Alexander, K. Kukar, S. Corcoran, D. Ouyang, C. Wong, E. J. Ramond, C. Rhiner, E. Moreno, B. Lemaitre, , K. Brueckner

The paper identifies the largest reservoir of blood cells in adult Drosophila and shows they control survival after bacterial infection by inducing Drosocin expression in surrounding tissues.

bioRxiv · Mar 16, 2019 · PreprintImmunology