Author

D. B. Weiner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Assay:proteomics· 5 Research Focus:drug response / drug discovery· 4 Organism:mouse· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2

Frequent Co-Authors

K. Schultheis· 6 shared M. Purwar· 5 shared D. Elwood· 4 shared I. Maricic· 4 shared J. J. Kim· 4 shared K. E. Broderick· 4 shared L. M. Humeau· 4 shared V. M. Andrade· 4 shared

Activity by Year

2020-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

K. Schultheis

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Author profile →

8 papers

Recent·Most cited

Targeting LxCxE cleft pocket of retinoblastoma protein in M2 macrophages inhibits ovarian cancer progression

E. N. Tcyganov, T. Kwak, X. Yang, A. N. R. Poli, C. Hart, A. Bhuniya, J. Cassel, A. Kossenkov, N. Auslander, L. Lu, P. Sharma, M. D. G. C. Mendoza, D. Zhigarev, M. G. Cadungog, S. Jean, , L. J. Montaner

This study shows targeting the LxCxE cleft pocket of Rb in M2 macrophages inhibits ovarian cancer progression by reducing immunosuppressive TAMs and enhancing T cell infiltration.

bioRxiv · May 10, 2024 · PreprintImmunology

Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primates

J. N. Walters, B. Schouest, A. Patel, E. L. Reuschel, K. Schultheis, E. Parzych, I. Maricic, E. N. Gary, M. Purwar, V. M. Andrade, A. Doan, D. Elwood, Z. Eblimit, B. Nguyen, D. Frase, , K. E. Broderick

bioRxiv · Oct 27, 2021Immunology

Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model

S. Jiang, S. Wu, G. Zhao, Y. He, L. Bao, J. Liu, C. Qin, J. Hou, Y. Ding, J. Wu, J. Yan, L. Humeau, A. Patella, D. B. Weiner, K. Broderick, B. Wang

This study compares a wild-type SARS-CoV-2 spike protein DNA vaccine with an optimized sequence in a mouse model, showing enhanced immune responses and protection against viral challenge.

bioRxiv · Aug 13, 2021Immunology

Design, immunogenicity and efficacy of a Pan-SARS-CoV-2 synthetic DNA vaccine

C. C. Reed, K. Schultheis, V. M. Andrade, R. Kalia, J. Tur, B. Schouest, D. Elwood, J. N. Walters, I. Maricic, A. Doan, M. Vazquez, Z. Eblimit, P. Pezzoli, D. Amante, M. Porto, , K. E. Broderick

This study designs and tests a DNA vaccine, INO-4802, which induces broad immunity against multiple SARS-CoV-2 variants in animal models.

bioRxiv · May 11, 2021 · PreprintImmunology

Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drive rapid and potent immunogenicity capable of single-dose protection

K. Konrath, K. Liaw, Y. Wu, X. Zhu, S. Walker, Z. Xu, K. Schultheis, N. Chokkalingam, N. J. Tursi, J. Du, M. Sullivan, M. Purwar, A. Moore, V. Machado, I. Maricic, , D. W. Kulp

This study develops glycan-modified SARS-CoV-2 nanoparticle vaccines that induce potent neutralizing antibodies and single-dose protection against SARS-CoV-2 in multiple animal models.

bioRxiv · Apr 28, 2021Immunology

INO-4800 DNA Vaccine Induces Neutralizing Antibodies and T cell Activity Against Global SARS-CoV-2 Variants

V. M. Andrade, A. Christensen-Quick, J. Agnes, J. Tur, C. Reed, R. Kalia, I. Marrero, D. Elwood, K. Schultheis, M. Purwar, E. Reuschel, T. McMullan, P. Pezzoli, K. Kraynyak, A. Sylvester, , K. E. Broderick

This study evaluates the efficacy of the INO-4800 DNA vaccine against SARS-CoV-2 variants, showing neutralizing antibodies and preserved T cell responses.

bioRxiv · Apr 14, 2021Immunology

Intradermal-delivered DNA vaccine provides anamnestic protection in a rhesus macaque SARS-CoV-2 challenge model

A. Patel, J. Walters, E. L. Reuschel, K. Schultheis, E. Parzych, E. N. Gary, I. Maricic, M. Purwar, Z. Eblimit, S. N. Walker, D. Guimet, P. Bhojnagarwala, A. Doan, Z. Xu, D. Elwood, , K. E. Broderick

This study evaluates an intradermal DNA vaccine against SARS-CoV-2 in rhesus macaques, showing it induces immune responses and provides protection against viral challenge.

bioRxiv · Jul 28, 2020 · PreprintImmunology

SARS-CoV-2 assays to detect functional antibody responses that block ACE2 recognition in vaccinated animals and infected patients

D. W. Kulp, S. Walker, N. Chokkalingam, E. L. Reuschel, M. Purwar, Z. Xu, E. Y. Gary, K. Y. Kim, K. Schultheis, J. Walters, S. Ramos, T. R. F. Smith, K. Broderick, P. Tebas, A. Patel, D. B. Weiner

The paper describes a rapid serological assay to detect functional antibodies blocking ACE2 recognition in vaccinated animals and infected patients.

bioRxiv · Jun 17, 2020Immunology