D. Zhang

This study shows P body factors coat germ granules in C. elegans to enable transgenerational gene silencing by maintaining small RNA factors and secondary small RNA amplification.

This study shows that P. multocida infection increases respiratory epithelial permeability in mice and humans by activating the HIF-1 and VEGFA signaling pathways.

This study uses scRNA-Seq to analyze B cells from allo-HCT patients, revealing molecular differences in B cell subsets associated with active versus non-active cGVHD.

This paper challenges claims of multiple SARS-CoV-2 spillovers by showing methodological flaws in genome analysis and phylodynamic modeling.

This study shows that disrupting mitochondrial Ca2+ homeostasis in Arabidopsis leads to misregulated gene expression and proteostatic responses, affecting plant growth and stress resistance.

The paper investigates sugarcane protoplast responses to enzymolysis using physiological, cytological, proteomic, and transcriptomic analyses, revealing changes in antioxidant activity, cell structure, and gene expression.

This study identifies multiple factors influencing mitogenomic evolutionary rates in flatworms, with parasitism having the greatest impact despite its monophyletic origin.

This paper engineers a precise adenine base editor, ABE9, with reduced bystander mutations and off-target effects, enabling efficient and accurate A-to-G editing in mouse and rat embryos.

This study shows that mitochondrial dysfunction triggers a retrograde signaling program that reduces cellular maturity in metabolic tissues, and blocking this signaling can restore cell identity and improve hyperglycemia.

This study examines age-related seroprevalence of four seasonal coronaviruses in children and postpartum women, showing waning passive immunity and resurgence of IgGs with age.

This study identifies BdPOX, a peroxidase, as a regulator of hair cell and stomatal size in Brachypodium distachyon, showing its role in cell wall modification and epidermal function.

The paper identifies incomplete lineage sorting in Sulfitobacter, a marine bacterium, showing rapid speciation driven by ancestral polymorphism retention rather than adaptive selection.

The paper identifies conserved plasmodesmal proteins through comparative proteomics across Arabidopsis and moss, revealing core components like β-1,3-glucanases and tetraspanins.

This study shows DNA viruses like TYLCV undergo intracellular population bottlenecks, limiting replication to no more than three genome copies per cell, ensuring lethal mutations are purged.

This study identifies FtMYB102 and FtbHLH4 as a transcriptional complex that promotes rutin accumulation in Tartary buckwheat by inducing CHI expression.

This study identifies DNALI1 as a key protein in sperm development, showing its role in the MEIG1/PACRG complex for cargo transport along the manchette and its involvement in sperm individualization.

The paper identifies two opposing polarity domains in subsidiary mother cells that regulate asymmetric division in grass stomata.

This paper models the fluke-and-glide gait of bottlenose dolphins and finds it reduces metabolic and mechanical costs of transport compared to continuous fluking.

The paper uses organoid models to show that WNT2B promotes vascularization in pregnancies, linking trophoblast function to vascular development in both intrauterine and ectopic pregnancies.

The paper introduces the Swarm, a high-throughput optogenetic platform for screening ion channel modulators in excitable cells, demonstrating its utility in drug discovery for nervous system disorders and cardiac toxicity.

The paper identifies YAB11-NGAL1 as a regulator of leaf serration in poplar through GWAS and eQTN mapping, showing its role in environmental adaptation and morphological plasticity.

This paper develops a novel murine model of mania through environmental stressors and validates it against depression models and controls.

This study reports cryo-EM structures of human enteropeptidase in multiple states, revealing its activation mechanism and substrate recognition process.

The paper uses cryo-EM to reveal cooperative conformational changes in KaiC hexamers that enable switch-like phosphorylation responses.

This study identifies Nr5a2 as a key driver of olanzapine-induced hyperphagia and weight gain by directly regulating Agrp expression in the hypothalamus.

This study shows that silencing the nt5 gene in Staphylococcus aureus reduces kidney abscess formation and enhances phagocytosis by host immune cells.

LIFE-Seq is a method for analyzing transgene integration in GMOs using DNA probes and PacBio sequencing, offering improved accuracy and cost-effectiveness compared to whole-genome sequencing.

This study shows that knocking out OsSWEET15 in rice reduces fertility by impairing embryo formation and seed-setting, with similar effects observed in OsSWEET11 mutants.

This study shows that GLH/VASA helicases are essential for forming germ granules, which ensure accurate piRNA-mediated transcriptome surveillance by distinguishing self from non-self.

This paper develops bright fluorophores and uses heavy water to improve fluorescence imaging of deep-buried hollow organs, achieving better visualization and diagnosis.