D. Zhao

This study identifies that SARS-CoV-2 nucleocapsid protein undergoes phase separation, which can be modulated by small molecules, offering new therapeutic strategies against COVID-19.

This paper shows that Mtb PknG acts as an unusual ubiquitinating enzyme by promoting ubiquitination of TRAF2 and TAK1 to suppress host innate immunity.

This study uses directed evolution to identify SH2 domain variants with enhanced binding to phosphotyrosine peptides, revealing differences in cross-reactivity with sulfotyrosine.

This study analyzes the transcriptome of potato leaves infected with Alternaria solani to identify gene expression changes and hormone responses associated with disease resistance.

This study identifies B-plexins as critical for mechanosensing in epidermal stem cells, linking mechanical feedback to cell division control during development and in cancer.

This paper validates a vascularized micro-tumor model for colorectal cancer that better replicates in vivo drug responses than traditional 2D or 3D models.

This study identifies Rv3194c as a hyaluronic acid-binding adhesin in Mycobacterium tuberculosis that facilitates lung epithelial interaction, with its binding site P91-110 serving as a potential therapeutic target.

This paper introduces LiveFISH, a method to visualize real-time chromosomal rearrangements in living cells, and demonstrates its application in detecting gene-editing induced translocations.

The paper identifies bivalent chromatin states and broad H3K4me3 domains associated with pro-metastatic drivers in melanoma using ChIP-sequencing data from tumor samples and cell lines.

This paper uses NMR to determine how P[8] and P[6] rotavirus VP8* domains bind to different histo-blood group antigens, revealing structural differences that may explain their distinct host ranges and evolutionary adaptations.

This study investigates microbial and metabolic succession on building materials under high humidity, finding that wetting and material type significantly influence microbial communities and metabolite profiles.

This study identifies the role of N-linked glycosylation in ZIKV E protein function across mosquito and human cells using a mutant library.

The paper identifies iridoid synthase enzymes in two Nepeta species and shows they do not determine nepetalactone stereochemistry, which is instead established later in the biosynthetic pathway.