Author

E. Petsalaki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2

Frequent Co-Authors

G. Giudice· 3 shared A. Dugourd· 1 shared A. J. Murray· 1 shared A. K. Overby· 1 shared A. P. Sowton· 1 shared A. S. Shun-Shion· 1 shared A. Sayadi· 1 shared A. Sousa· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersCell Biology

G. Giudice

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Limited oxygen availability in standard cell culture alters metabolism and function in terminally-differentiated cells

J. Tan, S. Virtue, D. M. Norris, O. J. Conway, M. Yang, C. Gribben, F. Lutgu, J. R. Krycer, R. J. Mills, I. Kamzolas, C. Pereira, M. Dale, A. S. Shun-Shion, H. J. Baird, J. A. Horscroft, , D. J. Fazakerley

This study shows that increasing oxygen levels in cell culture improves metabolic function and responsiveness in terminally differentiated cells like adipocytes and hepatocytes.

bioRxiv · Nov 29, 2022 · PreprintCell Biology

Phosphoproteomic profiling highlights CDC42 and CDK2 as key players in the regulation of the TGF-β pathway in ALMS1 and BBS1 knockout models

B. Bea-Mascato, G. Giudice, I. Pinheiro-de-Sousa, C. Solarat, E. Petsalaki, D. Valverde

The paper identifies CDC42 and CDK2 as key regulators of the TGF-β pathway in ALMS1 and BBS1 knockout models through phosphoproteomic analysis.

bioRxiv · Nov 4, 2022 · PreprintCell Biology

Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs

F. Mihalic, L. Simonetti, G. Giudice, M. Rubin Sander, R. Lindqvist, M. B. A. Peters, C. Benz, E. Kassa, D. Badgujar, R. Inturi, M. Ali, I. Krystkowiak, A. Sayadi, E. Andersson, H. Aronsson, , Y. Ivarsson

The paper uses phage-based screening to identify 1,712 virus-host interactions mimicking host short linear motifs, revealing therapeutic targets for broad-spectrum antivirals.

bioRxiv · Jun 19, 2022 · PreprintBiochemistry

Pan-Cancer landscape of protein activities identifies drivers of signalling dysregulation and patient survival

A. Sousa, A. Dugourd, D. Memon, B. Petursson, E. Petsalaki, J. Saez-Rodriguez, P. Beltrao

The paper analyzes protein activity changes in cancer using genomics and proteomics data to identify drivers of signaling dysregulation and their impact on patient survival.

bioRxiv · Jun 9, 2021Cancer Biology

Chromosomal arrangement of synthetic lethal gene pairs: repulsion or attraction?

S.-R. Hosseini, B. Wadie, E. Petsalaki

The paper analyzes synthetic lethal gene pairs in yeast and finds they are genomically closer in 2D and 3D space compared to random, contrasting with bacterial genomes where they are repelled.

bioRxiv · May 5, 2020 · PreprintEvolutionary Biology

Spatial Organization of Rho GTPase signaling by RhoGEF/RhoGAP proteins

P. M. Mueller, J. Rademacher, R. D. Bagshaw, K. M. Alp, G. Giudice, L. E. Heinrich, C. Barth, R. L. Eccles, M. Sanchez-Castro, L. Brandenburg, G. Mbamalu, M. Tucholska, L. Spatt, C. Wortmann, M. T. Czajkowski, , O. Rocks

The paper characterizes RhoGEF/RhoGAP substrate specificities, localization, and interactomes to reveal their role in spatially organizing Rho signaling.

bioRxiv · Aug 29, 2018Cell Biology