F. Liu

This study identifies FDA-approved drugs that inhibit urease activity in H. pylori, offering potential new treatments for infections.

This study shows that PPARD promotes pancreatic ductal adenocarcinoma in mutant Kras mice on high-fat diets, and its inhibition could be a therapeutic strategy.

This study shows that SR-A1 facilitates Leptospira phagocytosis by macrophages but also promotes bacterial dissemination and inflammation, worsening leptospirosis in mice.

The paper develops a mathematical model to explain cross-species differences in myofibroblast effects on cardiomyocytes, identifying transient K+ currents as a key factor.

This study identifies structural variants in Brassica oleracea genomes that contribute to morphological divergence between cauliflower and cabbage.

The paper identifies genetic incompatibilities from duplicated genes in Arabidopsis thaliana using GWAS and natural population data, showing how these incompatibilities coexist and are mitigated by additional gene copies.

The paper identifies CNS-specific immune alterations in COVID-19 patients with neurological symptoms, suggesting neuroinvasion and anti-neural autoimmunity as potential causes.

The paper presents the cryo-EM structure of the activated Roq1 NLR bound to XopQ, revealing direct effector recognition and resistosome activation mechanism.

This study compares the transcriptional responses of Vero cells infected with PEDV and MRV, finding PEDV lacks antiviral and immune effector gene activation but alters zinc finger proteins and TMPRSS13 expression.

This study identifies a cross-regulation mechanism between RpfG and HtsH1/HtsH2/HtsH3 proteins in Lysobacter that controls antibiotic biosynthesis without requiring RpfG's phosphodiesterase activity.

This study investigates SARS-CoV-2 neuroinvasion in human and mouse brains using organoids, in vivo models, and autopsies, finding evidence of neuronal infection and its consequences.

This paper develops a mouse model of SARS-CoV-2 using AAV-mediated hACE2 expression, showing type I interferons fail to control viral replication and drive pathology.

This study compares blood flow dynamics in a diseased left circumflex artery and its artificially restored version to identify flow characteristics linked to coronary artery disease risk.

The paper uses a two-step molecular approach to delimit species in the spider genus Heptathela, identifying 20 putative species from 180 sampled individuals.

This study improves cross-link identification in XL-MS by using FAIMS to enhance separation and sensitivity, increasing identification rates by 23-56%.

This study shows that knocking down both miR-21 and CXCR4 inhibits glioma progression more effectively than single-targeted knockdown, by suppressing PI3K/AKT and Raf/MEK/ERK pathways.

This study designs, synthesizes, and evaluates two peptidomimetic aldehydes as antiviral drug candidates targeting SARS-CoV-2 main protease, showing potent inhibition and anti-infection activity.

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.

The paper analyzes transcriptomic and proteomic data from a new cytoplasmic male sterile cotton line to identify differentially expressed genes and proteins involved in microspore abortion.

This study shows SPARC enhances insulin secretion by reducing RGS4 in pancreatic beta-cells, improving glucose tolerance in SPARC-deficient mice.

This paper develops a mechanochemical model to study how cell tension affects migration, showing it inhibits movement under persistent stimuli but can enhance migration under random noise.

The paper shows that mRNA transcripts for sodium and potassium channels form complexes during translation, coordinating their expression to regulate cardiac electrical activity.

The paper analyzes ancient DNA from museum specimens to show that Southern Chinese gray wolves form a distinct sub-population with genetic links to an extinct canid related to dholes.

This study identifies differentially expressed genes and pathways in small yellow croaker liver under heat and cold stress, providing insights into temperature stress responses for aquaculture improvement.

This study shows that 15-LOX-1 metabolism of LA in PI3P reduces LRP5 membrane levels, inhibits Wnt/β-catenin signaling, and suppresses colorectal tumorigenesis in mice.

This study shows that nutrient-stimulated histone acetylation regulates the islet epigenome to control adaptive insulin secretion, with Lsd1 playing a key role in this process.

This study shows HIV-1 Nef interacts with LMP7 to reduce immunoproteasome formation and MHC-I antigen presentation, aiding viral immune evasion.

This study shows STING activates the NLRP3 inflammasome by recruiting NLRP3 to the ER and deubiquitinating it, enhancing IL-1β secretion and inflammatory responses.