F. Xu

This paper optimizes a baculovirus system to efficiently produce all rAAV serotypes 1-13, achieving high yields and scalability for research and therapeutic applications.

The paper identifies negative durotaxis, where cells migrate toward softer environments, and shows that integrin adhesion and motor-clutch dynamics drive this behavior in glioblastoma and neurites.

This study evaluates Nanopore sequencing for differentiating Salmonella serotypes and variants with similar antigenic formulas using SNP analysis and prophage prediction.

This study reports the draft genome of Giardia muris, revealing evolutionary adaptations and metabolic differences compared to Giardia intestinalis.

This meta-analysis compares first-generation EGFR-TKI plus chemotherapy to EGFR-TKI alone in advanced EGFR-mutated NSCLC, finding improved ORR, PFS, and OS with the combination, but increased toxicity.

The paper develops an interpretable machine learning framework to identify gut microbiome features predictive of type 2 diabetes, validated across multiple cohorts and linked to metabolic outcomes.

This study examines gene and protein dynamics during metamorphosis in Pacific oyster Crassostrea gigas using transcriptomics and proteomics, revealing distinct gene regulation networks at different stages.

This study identifies host genetic variants associated with gut microbiome and examines causal relationships between gut microbiome and human complex diseases, revealing shared and distinct microbiome features.

The paper shows that boron deficiency reduces brassinolide accumulation by downregulating BR6ox1 and BR6ox2, thereby inhibiting root growth through BR signaling.

This study uses super-resolution imaging to show that E. coli SSB relocates from the inner membrane to the cell interior in response to DNA damage, forming foci for repair.

This study shows that the maize Gβ subunit controls both shoot meristem development and immune responses, with implications for optimizing growth and defense tradeoffs in crops.

This study uses rOMT to analyze glymphatic transport, showing faster solute speed in CSF and regional differences in brain parenchyma, with implications for neurodegenerative diseases.

This study determines the structure of the DCAF15-DDB1-DDA1-Indisulam-RBM39 complex, revealing how Indisulam promotes RBM39 degradation via a novel degron motif.

This paper introduces a method to achieve high-precision 3D nanoscopy across whole cells and tissues by retrieving the in situ point spread function from single-molecule data.

The paper performs single-cell RNA sequencing on TNBC tumors to identify novel immune cell subsets and their associations with survival and TCR signaling.

This paper uses a BPNN to classify emotional states in raven calls, identifying categories like alarm and singing.

This paper analyzes an HIV model with latent reservoir and immune impairment, identifying thresholds for post-treatment control and virus rebound based on CTL proliferation rates.

This paper introduces Hessian-SMLM, a method to reduce pixel-dependent readout noise in sCMOS cameras for single-molecule localization microscopy, improving imaging time resolution.

The paper shows that FEA2, a CLAVATA receptor, responds to two different CLE peptides by signaling through distinct downstream effectors CT2 and CRN.

The paper investigates how two clades of Vibrio parahaemolyticus evolved independently through acquisition of distinct pathogenicity islands, contributing to increased infections in the Northeast US.