H. H. Lee

Mefloquine-induced conformational shift in Cx36 N-terminal helix leading to channel closure mediated by lipid bilayer

The paper presents cryo-EM structures of Cx36 gap junction channels bound to inhibitors, showing how these molecules induce conformational changes leading to channel closure.

Predicting microbial growth conditions from amino acid composition

This paper develops genome-based models to predict microbial growth conditions using amino acid composition, showing high accuracy for oxygen tolerance, temperature, salinity, and pH.

Agarose disk electroporation method for ex vivo retinal tissue cultured at the air-liquid interface reveals electrical stimulus-induced cell cycle reentry in retinal cells

This paper introduces a submergence-free electroporation method for ex vivo retinal tissue cultured at the air-liquid interface, enabling efficient gene delivery and revealing electrical stimulus-induced cell cycle reentry in retinal cells.

MicrobeMod: A computational toolkit for identifying prokaryotic methylation and restriction-modification with nanopore sequencing

MicrobeMod identifies prokaryotic methylation and restriction-modification systems using nanopore sequencing, revealing 5mC and 6mA methylation patterns in diverse bacterial and archaeal strains.

Characterizing Low-cost Registration for Photographic Images to Computed Tomography

The paper compares low-cost photographic imaging methods with a 3-D camera for registering photographic images to CT scans, finding iPhone imaging has lower landmark error in some cases.

Structure of recombinant formate dehydrogenase from Methylobacterium extorquens (MeFDH1)

The paper determines the structure of recombinant formate dehydrogenase from Methylobacterium extorquens using cryo-electron microscopy, revealing a noncanonical active site and dynamic structural features.

The Salivary Microbiome and Predicted Metabolite Production are Associated with Progression from Barrett's Esophagus to Esophageal Adenocarcinoma

This study examines the salivary microbiome and its predicted metabolite production in relation to progression from Barrett's esophagus to esophageal adenocarcinoma, finding significant microbiome shifts and metabolic changes associated with neoplastic progression.

Implementation considerations for deep learning with diffusion MRI streamline tractography

This paper discusses implementation considerations for deep learning with diffusion MRI streamline tractography and provides an open-source implementation with comparable performance to existing algorithms.

Convolutional-recurrent neural networks approximate diffusion tractography from T1-weighted MRI and associated anatomical context

This paper develops a convolutional-recurrent neural network to approximate diffusion tractography from T1-weighted MRI, showing results comparable to traditional dMRI tractography.

Glucuronoxylomannan intranasal challenge prior to Cryptococcus neoformans pulmonary infection enhances cerebral cryptococcosis in rodents

This study shows that intranasal GXM administration before C. neoformans infection increases fungal burden in lungs and enhances brain invasion by disrupting the blood-brain barrier.

Phospholipase B is critical for Cryptococcus neoformans survival in the central nervous system

This study shows that phospholipase B (PLB1) is essential for Cryptococcus neoformans survival in the central nervous system, as its deletion reduces fungal load and virulence in mice.

Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

This study characterizes the biased agonism of CXCR4 and CXCR7, revealing differences in G-protein coupling, β-arrestin recruitment, and ERK1/2 activation.

Signature of N-terminal domain (NTD) structural re-orientation in NPC1 for proper alignment of cholesterol transport: Molecular dynamics study with mutation

This study uses molecular dynamics simulations to investigate how the R518W mutation in NPC1 affects its structure and cholesterol transport function, revealing a structural shift in the NTD that may impair NPC2 interaction.

Crystal structure of β-arrestin 2 in complex with an atypical chemokine receptor phosphopeptide reveals an alternative active conformation

The paper presents a crystal structure of β-arrestin 2 bound to a phosphopeptide from ACKR3, revealing an alternative active conformation distinct from β-arrestin 1.