R. Basto

Centrosome amplification primes for apoptosis and favors the response to chemotherapy in ovarian cancer beyond multipolar divisions

The paper shows centrosome amplification in ovarian cancer cells primes them for apoptosis and improves chemotherapy response, independent of multipolar divisions and chromosome instability.

Short-term molecular consequences of chromosome mis-segregation for genome stability

This study shows that aneuploidy can trigger chromosome instability (CIN) by causing DNA replication stress and continuous CIN, leading to genetically diverse cells with varying proliferation abilities.

Low centrosome numbers correlate with higher aggressivity in ovarian cancer

The paper analyzes centrosome numbers in ovarian cancers and finds that low centrosome numbers correlate with poor patient survival and mesenchymal subgroup enrichment.

Genetic instability from a single S-phase after whole genome duplication

This study shows that newly formed tetraploid human cells experience high DNA damage during the first S-phase, leading to abnormal karyotypes and genetic instability.

Drosophila neural stem cells show a unique dynamic pattern of gene expression that is influenced by environmental factors

The paper demonstrates dynamic, reversible silencing of GAL80 in Drosophila neural stem cells influenced by environmental factors, with implications for clonal experiments and brain mosaicism.

Microvilli-derived Extracellular Vesicles Govern Morphogenesis in Drosophila wing epithelium

The paper identifies microvilli as the source of extracellular vesicles that transport Hedgehog morphogen in Drosophila wing discs, revealing the role of Prominin-like protein and cytoskeletal components in this process.

CELL CYCLE ASYNCHRONY GENERATES DNA DAMAGE AT MITOTIC ENTRY IN POLYPLOID CELLS

This study shows that polyploid cells generate DNA damage at mitotic entry due to cell cycle asynchrony, contributing to genetic instability in Drosophila and mouse neural stem cells.

Chromosomes function as a barrier to mitotic spindle bipolarity in polyploid cells

This study investigates how increased DNA and centrosome content in polyploid cells leads to mitotic spindle multipolarity and chromosomal instability.

Gene editing can generate fragile bivalents in mouse oocytes

This study shows that excessive microtubule nucleation from fragmented acentriolar MTOCs in mouse oocytes leads to chromosome breakage during meiosis.