H. Hu

The paper shows that locus contraction and V(D)J recombination are regulated by circumventing CBE scanning impediments through Wapl-dependent cohesin dynamics.

The paper traces the evolution of sex determination in northern pike, revealing an ancient origin of the master sex-determining gene and recent transitions including Y-chromosome loss.

This paper identifies novel endocannabinoid epoxides that modulate TRPV1 and cannabinoid receptors, reducing inflammation and offering potential for new therapeutics.

This study uses scRNA-seq to analyze 110,745 cells from osteosarcoma tissues, identifying malignant subpopulations and TME components, and shows TIGIT inhibition enhances T-cell cytotoxicity.

This paper reanalyzes CT scan data of Oculudentavis and concludes it is a squamate, not a bird or archosaur, based on morphological evidence.

Knockout of 4CL1 in Populus reveals a 4CL5-dependent compensatory pathway for lignification with links to thiol redox balance and sulfur assimilation.

This study shows that Arabidopsis PPC2 is essential for growth at low CO2 by linking photorespiratory metabolism with primary metabolism and ABA signaling.

The paper compares subgenome asymmetry in artificial and natural allopolyploid genotypes, finding that variable genome components influence subgenome differences and suggest their consideration in polyploid evolution studies.

The paper examines 3D chromatin changes in T-ALL, identifies TAD fusion events linked to oncogene activation, and shows drug treatments can restore some interactions.

The paper presents the cryo-EM structure of the glucagon receptor bound to a ligand and G-protein, revealing structural insights into ligand efficacy and activation mechanism.

The paper shows ancestral subdivision can falsely signal homoploid hybridization in wheat's D lineage, challenging the belief that hybridization contributed to its origin.

This study compares microbial diversity patterns in top- and subsoils of temperate grasslands along an aridity gradient, finding contrasting diversity trends and drivers between soil depths.

This study shows that ischemic stroke alters pulmonary immunity independently of pneumonia by reducing immune cell percentages and chemokine levels in the lungs.

This study examines how drought affects the antioxidant system and stomatal aperture in Zanthoxylum bungeanum by analyzing enzyme activities, gene expression, and stomatal changes under drought conditions.

This study identifies and validates a novel QTL on chromosome 6HL in barley that confers resistance to Fusarium crown rot, explaining 29.1% of phenotypic variance.

This study reveals dynamic conformational landscapes of SETD8 using X-ray structures and molecular simulations, showing how protein dynamics influence catalysis and cancer-associated mutations.

This study uses metagenomic sequencing to identify pathogens in culture-negative infective endocarditis cases, providing antimicrobial resistance profiles without culturing.

This study shows that autophagy reduces lung injury by inhibiting the NF-κB pathway and inflammatory mediator release in hypoxia models.

The paper compares genomes and transcriptomes of termites and cockroaches to identify molecular mechanisms underlying termite eusociality, finding parallels and differences with Hymenoptera.

The paper identifies structural motifs in CIF1 and CIF2 required for complex formation and cytokinesis in Trypanosoma brucei.