H. Hu

The paper presents a high-resolution structure of the S1P5 receptor complexed with an inverse agonist, revealing structural features that explain receptor subtype selectivity and inverse agonism.

This paper develops a chimpanzee adenovirus-based vaccine against the SARS-CoV-2 Delta variant and shows it induces strong immunity and protects mice from challenge.

The paper identifies KEA3 as the main regulator of the PET/PMF relationship in diatoms, showing its role in modulating NPQ responses and light acclimation.

This study combines emodin with low-frequency low-intensity ultrasound to treat osteomyelitis by enhancing antibacterial and anti-biofilm effects through sonoantimicrobial chemotherapy.

This study reports cryo-EM structures of S1PR1 bound to different agonists, revealing activation mechanisms and a two-step transition process for CBP-307.

This study finds a negative correlation between soybean yield and the number of nucleotide-binding leucine-rich repeat (NLR) resistance genes.

This study shows that combining mRNA vaccines targeting the SARS-CoV-2 spike and nucleoprotein proteins enhances protection against the delta variant in animal models.

The paper investigates TRPA1 expression in oral cancer cell lines and normal cells, finding TRPA1 absent in cancer cells, suggesting its potential as a prognostic indicator.

This study shows that gasdermin signaling is essential for fracture healing, as its absence delays bone callus formation and reduces biomechanical properties.

This study shows that oral administration of BefA from E. coli reduces blood glucose and improves beta cell function in both T1DM and T2DM mice.

Mutations in the auxin importer gene Spp1/SvAUX1 reveal broad developmental effects in shoots, inflorescences, and flowers, with non-redundant roles among AUX1 homologs.

This study maps haplotype variation at the cqProt-003 locus in soybean, identifying structural variants and tandem repeats associated with high protein content and tracing their distribution across wild, landrace, and cultivated populations.

This paper demonstrates that intranasal nanobody Nb22 provides short-term instantaneous prophylaxis and effective treatment against SARS-CoV-2 in hACE2 mice, with ultrahigh potency and long-lasting retention in the respiratory system.

The paper examines how selection for seed size in oats has influenced the abundance of specialized metabolites, finding uneven effects on different metabolite classes.

This study evaluates methods for creating gastrojejunostomy using magnetic compression and pyloric ligation in rabbits, finding that pyloric ligation provides better long-term patency than paclitaxel-loaded magnets.

The paper shows that CD4-targeted bacteriophage T4 nanoparticles reactivate HIV-1 latency in CD4+ T-cells without global activation or cytokine storm.

This study examines how nitrification inhibitors and straw incorporation affect N2O emissions and microbial communities in different cropland soils, finding that their effects vary by soil type.

This study identifies five new Asgard archaeal phyla, expands the Asgard superphylum, and supports the origin of eukaryotes within Archaea.

The paper develops three RORγt inhibitors that reduce Th17 differentiation and inflammation in vivo and inhibit tumor growth in PDAC organoids.

This study identifies five new Asgard archaeal phyla, expands the Asgard superphylum, and supports a 2-domain tree of life by showing Tyrarchaeota as a deeper branching lineage than Heimdallarchaeota.

This study identifies CCR2- resident cardiac macrophages as critical for adaptive myocardial remodeling in heart failure, showing their role in ventricular remodeling and coronary angiogenesis.

This study identifies tachykinin peptides as regulators of task-specific behavioral responsiveness in honeybee workers by manipulating their expression and observing behavioral outcomes.

The paper identifies peptide ancestry informative markers (pAIMs) that correlate with ancestry in uterine neoplasms, showing they can accurately determine ancestry proportions with high precision.

This study maps the glycolytic targetome in cancer cells using TRAP, revealing 913 targets and 2,487 interactions for 10 glycolytic metabolites and their functional roles in cancer biology.

The paper reports the cryo-EM structure of pufferfish TMEM206, revealing its trimeric architecture and chloride ion selectivity, and compares it to sodium channels despite sequence differences.

This study investigates how light intensity affects the coloration and structure of chimeric leaves in Ananas comosus var. bracteatus, finding that 50% shade optimizes growth and ornamental value.

This study shows that LRRC26-associated BK channels in goblet cells protect mice from colitis by regulating potassium flux and MUC2 secretion.

The paper examines mRNA expression patterns across nine species to assess the applicability of Haeckel's postulates, finding partial conservation and alignment with terminal edition patterns.

This study develops a simplified method to induce RPE-like cells from human fibroblasts and validates their properties using single-cell RNA sequencing.

The paper shows that methylation of Aub by piRNA loading is essential for piRNA amplification and transposon silencing in Drosophila.