H. Xie

This paper introduces a method to observe 3D subcellular dynamics in vivo at high resolution and speed, demonstrating its application in various biological systems.

This study identifies NtMED25 as a mediator subunit that interacts with NtMYC2s to regulate nicotine biosynthesis in Nicotiana tabacum by enhancing gene expression.

This study examines how influenza antibodies change structurally and functionally during pregnancy, showing reduced inflammation and increased antibody retention.

The paper presents a high-resolution cryo-EM structure of mitochondrial complex I from Yarrowia lipolytica, revealing proton translocation pathways and conformational changes linked to proton pumping.

The paper identifies defective viral genomes (DVGs) in clinical urine samples of BK and JC polyomaviruses, showing their association with higher viral loads and genomic rearrangements.

The paper introduces a microchip called NOMA that enables sequential tracking of secretions from the same single cells with high retention efficiency.

This study shows that low-disturbance farming practices improve deep soil health, microbial diversity, and crop yield over ten years, supporting sustainable agriculture.

This study uses deep sequencing to characterize full-length TprK diversity in T. pallidum strains from human infections, revealing near-complete sequence divergence and estimating high antigenic variation potential.

This study uses a new computational tool to analyze antibody repertoires in ferrets after repeated influenza infections, finding that broadly neutralizing antibodies can emerge despite original antigenic sin.

This study shows that Zika virus-based immunotherapy improves long-term survival in mice with brain tumors by boosting memory T-cell levels.

This study examines how SARS-CoV-2 induces antiviral host responses, showing differences by viral load, age, and sex in gene expression profiles from infected individuals.

This paper shows SARS-CoV-2 ORF6 interacts with Rae1 and Nup98 to disrupt nucleocytoplasmic transport, reducing reporter expression and causing nuclear mRNA accumulation, more strongly than SARS-CoV ORF6.

This paper identifies and characterizes the NIC1-locus in tobacco, showing it regulates nicotine biosynthesis through ERF genes that function downstream of NtMYC2 in the JA signaling pathway.

The paper compares genomic sequences and full-length TprK profiles of two T. pallidum isolates from the same patient to understand reinfection genetics and immune evasion mechanisms.

This paper introduces a 3D-printed modular LEGO-like cage scaffold system for tissue engineering that allows scalable assembly and controlled therapeutic loading.

This study shows HPV+ HNSCC exosomes containing miR-9 polarize macrophages to M1, increasing tumor radiosensitivity.

The paper detects highly fragmented CMV nucleic acid in maternal cfDNA and shows its distinct fragment length distribution compared to human cfDNA, which may explain discrepancies in qPCR measurements.

This study shows that the I232T SNP in FcγRIIB causes structural changes that reduce ligand binding, contributing to SLE pathogenesis.

This study shows anti-HA stem antibodies neutralize influenza A virus by inhibiting neuraminidase activity, with implications for therapeutic synergy with NA inhibitors.

This study uses next-generation sequencing to determine the mutation bias caused by favipiravir in influenza virus RNA, showing it primarily acts as a guanine analogue and secondarily as an adenine analogue.

This paper develops a mouse model with a human GNAO1 G203R mutation, showing sex-specific movement and seizure differences.

This study sequences HHV-6B and iciHHV-6 genomes, identifies geographic clustering and recombination in active infections, and reannotates the HHV-6B genome using transcriptomics and proteomics.