H. Zhou

This study evaluates the neutralization of SARS-CoV-2 Omicron BA.2 by therapeutic monoclonal antibodies, finding reduced neutralization by several antibodies but retention of activity by the AZD8895+AZD1061 cocktail.

The paper determines the structure of the ankyrin complex on human red blood cells and elucidates its assembly mechanism and role in mechanical stability.

The paper shows that actin remodelling facilitates RPAC translation under stress, maintaining proteasome homeostasis in yeast.

This study uses single-cell RNA sequencing to identify five MSC subpopulations, revealing distinct developmental trajectories and functional roles in self-renewal and immunoregulation.

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

The paper isolates and identifies bacterial strains from deep-sea water and sediments in the Mariana Trench, finding that environmental factors shape culturable bacterial diversity.

This study reports the crystal structure of the Omicron SARS-CoV-2 RBD-ACE2 complex and identifies key mutations enhancing ACE2 binding and immune escape.

This study evaluates neutralization of SARS-CoV-2 Mu and C.1.2 variants by vaccine-elicited and convalescent antibodies, finding that vaccine-induced responses remain protective despite partial resistance.

The paper assesses Omicron's resistance to vaccine and monoclonal antibody neutralization, finding boosters improve efficacy but existing therapies are largely ineffective.

This study optimizes excitation wavelength and emission window for SPNs to improve imaging quality, showing L1057 NPs achieve superior resolution and signal-to-background ratio in the NIR-IIb window.

This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.

This study identifies GRP78 as a positive regulator of HBV enveloped-particle secretion through direct interaction with preS1, suggesting it as a potential therapeutic target.

The paper shows that C4 and CAM photosynthesis are integrated in Portulaca oleracea, with both carbon fixation and metabolite use occurring in the same cells under drought.

This study evaluates off-target mutations caused by high-activity adenine base editors in rice, finding that TadA9 variants and CRISPR/SpCas9n-NG increase off-target A>G SNVs, with RNA mutations clustering more than DNA mutations.

The paper identifies multi-site phosphorylation of Mif2/CENP-C as essential for inner kinetochore assembly and accurate chromosome segregation in yeast.

ReCOV, a trimeric SARS-CoV-2 subunit vaccine, induced neutralizing antibodies and complete protection against SARS-CoV-2 in mice and rhesus macaques.

This study identifies a non-metabolic role of nuclear PHGDH in liver cancer by promoting neutrophil recruitment through the PHGDH/cMyc/AF9 axis, suggesting it as a therapeutic target.

This study shows that flagellin FLiC enhances upland cotton resistance to Verticillium dahliae by inducing immune responses and modulating calcium, hydrogen peroxide, and nitric oxide pathways.

This study shows that Celastrol reduces colitis by modulating gut microbiota, improving immune balance, and increasing metabolites like pyruvate and adenosine.

This study shows that mitochondrial UPR suppresses wounding-induced innate immunity in C. elegans epidermis by inhibiting ATFS-1 and modulating downstream signaling pathways.

The paper links microbiome-derived proteins to disease-associated human pathways using metagenomic and protein-protein interaction analyses.

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

This study shows that a protein-based RBD-C-tag vaccine candidate provides protection against multiple SARS-COV-2 variants in mice.

This study identifies ribosomal protein L23 as a driver of hepatocellular carcinoma metastasis by upregulating MMP9 expression and promoting tumor growth and metastasis in vivo.

This study compares neutralizing antibody titers from mRNA and adenoviral vector vaccines against SARS-CoV-2 variants, finding lower neutralization against variants for Ad26.COV2.S and suggesting a second dose may improve protection.

This study assesses the neutralization efficacy of convalescent sera and mRNA vaccine-elicited antibodies against the SARS-CoV-2 lambda variant, finding minimal reduction in neutralizing titers.

This paper identifies Rad52's role in facilitating class-switch DNA recombination to IgD through microhomology-mediated alternative end joining, involving Zfp318 modulation and phosphorylation.

This study evaluates a nanoparticle vaccine against SARS-CoV-2 variants, showing it induces strong immune responses and protection in mice and baboons against multiple variants.

This study shows that BSCL2 deficiency in the heart causes heart failure through excessive lipid catabolism, reduced energy reserves, and ATP levels, which can be mitigated by inhibiting fatty acid oxidation or high-fat diet.

This study uses deep metagenomics to explore microbial communities in Challenger Deep sediment, revealing new MAGs, metabolic functions, and virus-host interactions in hadal zone ecosystems.