H. Zhou

This study shows that loss of WNT5A and WNT5B in mice protects against DSS-induced colitis by reprogramming spleen neutrophils to suppress inflammation.

This study annotates IGH germline genes in three bat species and analyzes the CDR3 repertoire of Rhinolophus affinis, revealing unique immunological features that may explain asymptomatic viral infections in bats.

This study shows that the FER-CAR module regulates plasma membrane nano-organization and immune signaling through a feedback loop during RALF1 signaling.

This study develops a sessile drop chip to create 3D spheroids of fibroblasts and macrophages, showing that M2 macrophages enhance fibroblast proliferation and differentiation in a wound-healing model.

This study demonstrates that an ACE2 receptor decoy protein effectively reduces SARS-CoV-2 virus loads in mice against both parental and Omicron variants.

The paper establishes a reference library of TCR-beta germline genes in three bat species and analyzes the TCR-beta repertoire diversity in an additional bat species.

This study identifies Cul5 as a negative feedback regulator of CD8+ T cell signaling and anti-tumor activity, showing its knockout enhances tumor control through proteomic and signaling changes.

This paper develops a CRISPR/Cas12a-based genome editing method for bacterial plant pathogens without donor DNA, enabling efficient gene knockout and multiplex editing in Xanthomonas oryzae pv. oryzae.

This study identifies MHC class II expression in metastatic breast cancer cells and shows its role in immune evasion and tumor progression through IFN-gamma and JAK/STAT signaling.

This paper introduces a cryoFIB milling workflow for isolating objects of interest from large tissue samples, resulting in thin lamellae suitable for cryo-electron tomography.

This study shows gut commensals degrade extracellular matrix components in vitro and links this activity to IBD progression through proteolytic and enzymatic mechanisms.

The paper introduces a method to detect and analyze i6A-modified RNA with single-base resolution using iodine-mediated oxidation and reverse transcription.

This study identifies ZmEREB57 as a maize AP2/ERF transcription factor that enhances salt stress tolerance by regulating OPDA and JA signaling through two distinct pathways.

This study develops synNotch T cells that deliver IFN-gamma to neuroblastoma cells, restoring HLA expression and enhancing T cell-mediated killing without increasing immune checkpoints or systemic IFN-gamma.

This paper identifies a new family of 'Ca. Nanohaloarchaeota' from hypersaline environments, showing they are an intermediate stage in the evolution of symbiosis with Halobacteria.

The paper develops chemical labeling strategies to tag lipid-modified RNAs and identify new regulatory enzymes involved in prenylation.

The paper catalogs 19,251 non-human reference genomes from Qinghai-Tibetan Plateau animals, revealing new insights into mammalian gut microbiome diversity and host-microbe interactions.

This study identifies endothelial SIRPα signaling as critical for thymic progenitor homing, T cell regeneration, and antitumor immunity through CD47-SIRP interactions and VE-cadherin endocytosis.

The paper determines the in situ atomic structures of VSV components using cryoEM and sub-particle reconstruction, revealing their assembly mechanism through interactions.

This paper identifies 15 genome-wide significant loci for maximum habitual alcohol intake (MaxAlc) in 247,755 U.S. Veterans and shows strong genetic correlations with alcohol use disorder and psychiatric traits.

This study engineers macrophages to inducibly secrete TRAIL in response to the tumor microenvironment, showing improved anti-tumor effects and reduced side effects in preclinical models.

This study shows Streptococcus pneumoniae promotes lung tumorigenesis by activating PI3K/AKT and NF-kB pathways through PspC-PAFR binding in lung cancer cells.

This study identifies a Delta-Omicron recombinant SARS-CoV-2 variant that escapes Sotrovimab neutralization, highlighting the role of recombination in immune escape.

This study shows that breast cancer stem cells escape γδ T cell immunosurveillance by losing key ligands and antigens, and that this escape can be reversed with Zoledronate or IFN- treatment.

This paper introduces VENAS, a system for analyzing SARS-CoV-2 genome evolution networks, enabling rapid processing and visualization of large datasets to trace viral mutations and transmission.

The paper shows that a bacterial E1-E2 fusion protein, Cap2, primes cGAS for antiviral signaling through a process called cGASylation, which increases cGAMP production by ~50-fold.

This study investigates the structural and biochemical basis of early FER receptor kinase signaling in Arabidopsis, revealing an active conformation and the role of Tyr phosphorylation in substrate activation.

The paper identifies Lnc956 as a non-coding RNA that forms a complex with TRIM28 and HSP90B1 to prevent replication fork collapse and maintain genomic stability in mouse embryonic stem cells.

The paper presents a cryo-EM structure of α-synuclein fibrils with the A53E mutation, showing structural differences that may affect aggregation kinetics and disease progression.

This study quantifies how anatomical traits of Coffea arabica leaves influence photosynthesis using correlation and path analysis, identifying leaf thickness and stomatal density as key factors.