H. Zhou

This study evaluates the neutralization resistance of SARS-CoV-2 B.1.617 and B.1.618 spike proteins to vaccine-elicited and therapeutic antibodies, finding partial resistance due to specific mutations.

This study identifies unbalanced dietary patterns as contributors to precocious puberty by altering gut microbiota and host metabolites, with biomarkers showing high diagnostic accuracy.

The paper assesses neutralization of B.1.526 SARS-CoV-2 variants by vaccine-elicited and therapeutic antibodies, finding minimal impact on neutralizing titers.

The paper identifies novel bat coronaviruses, including relatives of SARS-CoV-2, from a region in China, providing insights into their evolutionary origins and geographic distribution.

The paper investigates the relationship between NDRG1 expression, DNA methylation, and DNMT family in gastric cancer, finding DNMT1 correlates with prognosis.

This study evaluates the neutralization activity of two monoclonal antibodies against SARS-CoV-2 variants, finding reduced efficacy against B.1.351 and mink cluster 5 due to specific spike protein mutations.

The paper determines the native structure of the RhopH complex from malaria parasites using cryo-EM and mass spectrometry, revealing insights into its assembly and trafficking.

This study identifies a mechanism for regulated kinetochore sumoylation by showing that Ulp2 recruitment to Ctf3/CENP-I controls sumoylation levels and chromosome segregation.

This paper introduces delta-melt, a method using chemical modifications and melting experiments to measure thermodynamic preferences for non-native DNA conformations, revealing sequence-specific variations in conformational stability.

CDKL5 is a DNA damage-sensing kinase that modulates transcriptional activity near DNA breaks.

This study shows that 1 μM Dexmedetomidine reduces H9C2 cardiomyocyte injury under hypoxia/reoxygenation by partially inhibiting endoplasmic reticulum stress.

This study identifies abundant and diverse circRNAs from SARS-CoV-2, SARS-CoV, and MERS-CoV, revealing a novel type of circRNA distinct from DNA-encoded circRNAs.

AlphaTracker is a computer vision tool for multi-animal tracking and behavioral analysis, designed for ease of use and real-time performance in studying social interactions in mice.

This study identifies clonal subpopulations in glioblastoma core and edge lesions and shows that NAD+ depletion via CD38 inhibition reduces tumor edge formation.

This paper develops a droplet-based microfluidics platform for high-throughput functional antibody screening, identifying potent cancer immunotherapeutics like CD40 agonists and anti-Her2/anti-CD3 bispecific antibodies.

This study evaluates the efficacy of STI-2020 antibody delivered post-infection via intranasal or intravenous routes in a hamster model of COVID-19, showing reduced disease severity and duration.

This study identifies serum sphingolipids associated with insulin sensitivity using lipidomics and glucose clamp techniques, finding SM/Cer and SM d18:0/26:0 as potential biomarkers.

The paper shows that β-Amyloid peptides modulate the switching behavior of donor-acceptor Stenhouse adducts, reducing molecular switching rates and inhibiting aggregation.

This study identifies and develops human SARS-CoV-2 neutralizing antibodies using a phage display library, showing their efficacy in vivo against the virus.

This study shows SpRY expands CRISPR editing in rice by recognizing diverse PAMs, enabling efficient genome modification across various loci.

This study benchmarks seven single-cell RNA-seq methods for immune cell profiling, finding that 10x Genomics 5 v1 and 3 v3 show higher sensitivity and fewer drop-out events.

This study shows that human lung organoids can model SARS-CoV-2 infection and drug response, revealing virus targets and effective antiviral treatment.

The paper analyzes the airway microbiome in COPD patients at species and strain levels, revealing intra-genus diversity linked to inflammatory phenotypes and clinical outcomes.

The paper identifies GRL0617 as a non-covalent inhibitor of SARS-CoV-2 PLpro with an IC50 of 2.1 μM, supported by co-crystal and NMR data showing its mechanism of action.

This study shows that excessive polyamine production in keratinocytes drives self-RNA sensing by dendritic cells, contributing to psoriasis inflammation.

This study shows that loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy by promoting fibrosis through Wnt signaling and EndMT/EMT mechanisms.

This paper develops a S1-Fc vaccine targeting antigen-presenting cells, showing it elicits protective anti-SARS-CoV-2 IgG and T cell responses, with high protection at low doses.

This study evaluates the immunogenicity and protective efficacy of the NVX-CoV2373 SARS-CoV-2 vaccine in baboons and mice, showing strong immune responses and protection without enhanced disease.

This study shows the SARS-CoV-2 envelope protein causes ARDS-like damage and identifies channel inhibitors as potential antiviral targets.

The paper investigates how the HSV-1 nuclear egress complex (NEC) forms a curved coat around the capsid by interacting with UL25 at pentagonal vertices, enabling nuclear egress.