J. Hong

This study demonstrates that intracorneal delivery of HSV-1-targeting CRISPR/Cas9 mRNA prevents herpetic stromal keratitis in both animal models and human-derived corneas.

This paper demonstrates that the immunoPET agent [89Zr]Zr-DFO-TAB-H14 specifically and stoichiometrically binds to GPC3 in human liver cancer models, serving as a potential in vivo sensor for HCC diagnosis and therapy selection.

This study identifies genetic features of recurrent pancreatic cancer through sequencing and finds that treatment-induced genetic changes and potential second primary tumors influence recurrence.

This study identifies Vav1's role in regulating HIF-1α and GLUT-1, showing that Vav1 deficiency reduces glucose uptake in the brain and impairs learning.

The paper identifies NGP as a secreted murine protein that inhibits LPS function by blocking its interaction with TLR4.

This study shows hypoxia suppresses lysosomal activation and RTK degradation, linking oxygen tension to lysosomal function and suggesting lysosomal activation as a therapeutic target in cancer.

This study shows Vav1 is essential for HIF-1α activation in vascular response to ischemic stress, revealing a regulatory mechanism similar to HIF-1.

This study develops a primary gill epithelial cell model from olive flounder to propagate VHSV, showing increased cell viability with higher fetal bovine serum concentration.

This paper establishes the first reverse genetics system for a segmented negative-strand RNA plant virus, enabling molecular genetic analysis of its life cycle and pathogenicity.

The paper identifies genetic and transcriptional features of basal-like subtypes in pancreatic ductal adenocarcinoma, linking them to squamous histology and chromatin modifier mutations.

The paper uses decoy E3 ubiquitin ligases to identify new regulators of the plant circadian clock, showing redundancy in PUB59 and PUB60's role in gene splicing and circadian period control.

The paper identifies 5hmC signatures in cfDNA as accurate biomarkers for detecting colorectal and gastric cancers, outperforming conventional markers and matching tissue biopsy results.