Author

L.-O. Albulescu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 4 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Organism:human· 1 Assay:protein sequence· 1

Frequent Co-Authors

N. R. Casewell· 5 shared E. Crittenden· 4 shared R. A. Harrison· 4 shared C. A. Dawson· 3 shared J. Kool· 3 shared J. M. Gutierrez· 3 shared K. E. Bartlett· 3 shared S. Ainsworth· 3 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersPharmacology & Toxicology

N. R. Casewell

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Author profile →

5 papers

Recent·Most cited

Dermonecrosis caused by spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib

K. E. Bartlett, S. R. Hall, S. A. Rasmussen, E. Crittenden, C. A. Dawson, L.-O. Albulescu, W. M. Laprade, R. A. Harrison, A. J. Saviola, C. M. Modahl, T. P. Jenkins, M. C. Wilkinson, J. M. Gutierrez, N. R. Casewell

This study identifies toxin synergism in spitting cobra venom causing dermonecrosis and shows that varespladib prevents tissue damage in mouse models.

bioRxiv · Jul 20, 2023Pharmacology & Toxicology

Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms

S. R. Hall, S. A. Rasmussen, E. Crittenden, C. A. Dawson, K. E. Bartlett, A. P. Westhorpe, L.-O. Albulescu, J. Kool, J. M. Gutierrez, N. R. Casewell

The paper shows repurposed drugs and their combinations reduce cytotoxicity of snake venoms in cell and mouse models, offering potential new treatments for snakebite envenoming.

bioRxiv · May 20, 2022Pharmacology & Toxicology

Convergent Evolution of Pain-Inducing Defensive Venom Components in Spitting Cobras

T. D. Kazandjian, D. Petras, S. D. Robinson, J. van Thiel, H. W. Greene, K. Arbuckle, A. Barlow, D. A. Carter, R. M. Wouters, G. Whiteley, S. C. Wagstaff, A. S. Arias, L.-O. Albulescu, A. von Plettenberg Laing, C. Hall, , N. R. Casewell

This study shows that three spitting cobra lineages independently evolved venom with increased pain-enhancing toxins, likely in response to hominin emergence.

bioRxiv · Jul 8, 2020Evolutionary Biology

A combination of two small molecule toxin inhibitors provides pancontinental preclinical efficacy against viper snakebite

L.-O. Albulescu, C. Xie, S. Ainsworth, J. Alsolaiss, E. Crittenden, C. A. Dawson, R. Softley, K. E. Bartlett, R. A. Harrison, J. Kool, N. R. Casewell

This study shows that a combination of two small molecule inhibitors effectively neutralizes viper venom in vitro and prevents lethality in vivo across multiple regions.

bioRxiv · May 13, 2020Pharmacology & Toxicology

Preclinical validation of a repurposed metal chelator as a community-based therapeutic for hemotoxic snakebite

L.-O. Albulescu, M. Hale, S. Ainsworth, J. Alsolaiss, E. Crittenden, J. J. Calvete, M. C. Wilkinson, R. A. Harrison, J. Kool, N. R. Casewell

This paper shows that the metal chelator DMPS can effectively treat hemotoxic snakebite in mice, both when given orally and in combination with antivenom.

bioRxiv · Jul 28, 2019Pharmacology & Toxicology