J. Kim

The paper identifies a Burkholderia polyketoacyl-CoA thiolase with significantly higher TAL production activity than 2-PS, achieving 2.8 g/L in E. coli fermentations.

The paper investigates the interaction kinetics of the SBP with a type II ABC importer using FRET, revealing a locked complex formation that requires ATP hydrolysis and is inhibited by ATP or B12 binding.

This study uses smFRET to observe real-time ATP-driven translocation of B12 through the E. coli BtuCD-F transporter, revealing two sequential conformational changes.

This study shows CD244 inhibits macrophage maturation in melanoma, enhancing T cell responses and improving tumor rejection when combined with PD-L1 blockade.

This paper introduces HITAG, a method for high-throughput tagging of endogenous loci to study protein function, and demonstrates its use in analyzing stress granule-associated proteins.

This paper introduces a vortex ultrasound technique for endovascular sonothrombolysis that significantly improves clot lysis rates in cerebral venous sinus thrombosis.

This study identifies remote stress-focusing regions in intestinal anastomoses using geometric analysis, FEM, and in-vivo experiments, showing collagen fiber re-orientation correlates with stress distribution.

The paper identifies contributions of non-synonymous, synonymous, and non-coding variants to recurrent biological processes in retinoblastoma progression using genomic and functional analyses.

This study characterizes the SidC NRPS involved in fungal siderophore biosynthesis, revealing non-canonical mechanisms in peptidyl siderophore assembly.

This paper develops a baculoviral DNA vaccine targeting the SARS-CoV2 Delta variant, showing 100% survival against Delta and Omicron in mice, compared to 50% survival with the original vaccine.

This study develops a bilayer hydrogel that encapsulates genetically engineered bacteria, enabling long-term viability and controlled release for engineered living materials.

This study identifies the molecular pathway in Pseudomonas putida KT2440 for selenite reduction to selenium nanoparticles, linking sulfur metabolism and oxidative stress response.

This paper introduces a geometric descriptor based on integrated Gaussian curvature to predict surgical success in aortic dissections by analyzing shape changes.

The paper develops a sequence generation model using transfer and active learning to efficiently discover binding antibodies with novel HCDR3 regions, requiring only six thousand data points per antigen.

This paper develops a temperature-controlled self-replicating RNA vaccine that elicits cellular immunity and can be used as a pan-coronavirus booster.

This study shows that mitochondrial complex I defects in thyroid cancer drive reliance on aerobic fermentation, which can be targeted with lactate dehydrogenase inhibitors.

This study identifies phylogenetic clusters and the gene cfrA as factors contributing to cold stress tolerance in Campylobacter jejuni.

This study shows that m6A modification of MAPK13 mRNA by the METTL3-METTL14-WTAP complex promotes its degradation, and rapamycin stabilizes MAPK13, which enhances anti-cancer effects when silenced.

This study shows that loss of ZFP36 promotes NF-κB activation and phenotypic plasticity in prostate cancer, leading to aggressive disease and castration resistance, which can be reversed by NF-κB inhibition.

This paper identifies ALT in pediatric high-grade gliomas without ATRX mutations and links it to germline MMR variants.

This study uses longitudinal metatranscriptomic sequencing of wastewater to track antibiotic resistance genes and microbial activity across 16 million people in Southern California.

This study develops a high-throughput phenotyping platform to assess Aphanomyces root rot resistance in field pea, identifies 260 SNPs associated with resistance, and discovers both known and novel genes involved in immunity.

The paper uses fluorescence microscopy to study protein clusters before condensation, finding dynamic clusters that are not freely diffusing and exist even in unstressed cells.

The paper identifies intratumoral niches involving mregDC and CXCL13+ Th cells that support CD8 T cell differentiation following PD-1 blockade in HCC patients.

The paper uses population genomic analysis to trace multiple introductions of fall armyworm into Asia and Australia, showing human-assisted spread via trade and identifying genetic melting pot dynamics.

This study evaluates the effectiveness of a DNA booster vaccine in enhancing immune responses in mice previously vaccinated with either an mRNA or inactivated SARS-CoV-2 vaccine.

This study shows Pseudomonas aeruginosa forms mucus-associated biofilms in human airway models by contracting mucus using type IV pili.

This study shows that antibiotic tolerance in Campylobacter jejuni induced by ciprofloxacin and tetracycline leads to rapid development of fluoroquinolone resistance.

This study identifies the PPARγ/ETV2 axis as a novel pathway that suppresses endothelial-to-mesenchymal transition in pulmonary hypertension.

This paper trains a deep learning model to detect involved and uninvolved regions in H&E-stained colonic tissues of mouse colitis models to improve histopathological analysis.