J. Kim

This study develops nanobody antagonists against the AT1R receptor, showing they can selectively bind and modulate the receptor with tunable ligand selectivity.

This study evaluates frontal hip exoskeleton assistance for reducing walking metabolic cost but finds no reduction in metabolic rate with optimized control schemes.

This study evaluates a DNA vaccine, PlaCCine, showing strong immunogenicity and protection in mice against SARS-CoV-2 variants.

This study shows that the KCNK16 L114P mutation causes neonatal diabetes and glucose dyshomeostasis in adult mice by disrupting islet insulin secretion and increasing glucagon secretion.

This study shows that hyperglycosylation of prosaposin in tumor DCs leads to immune escape by impairing antigen presentation and T cell activation.

This study shows that the agr quorum-sensing system in Staphylococcus aureus primes the bacteria to resist oxidative stress by controlling reactive oxygen species, even when the system is not actively activated.

This study shows that aliphatic aldoximes repress phenylpropanoid production and that altered methionine metabolism affects plant growth and development in Arabidopsis.

The paper shows that nutlin-3a induces methuosis-like cell death in KRAS mutant NSCLC cells dependent on GFPT2.

The paper analyzes telomeric repeat motifs in nematodes using genome assemblies and subtelomere structures to reveal evolutionary changes in TRMs.

This study shows that E-cadherin upregulates the serine synthesis pathway in breast cancer cells, supporting proliferation and metastasis by providing metabolic precursors and resistance to oxidative stress.

This study identifies an acidic dipeptide in NIS that mediates AP2 binding, showing chloroquine enhances NIS membrane retention and RAI uptake in thyroid cancer.

The paper identifies a new RiPP subclass, pimtides, by analyzing the evolutionary spread of PIMT enzymes and their role in modifying precursor peptides.

The paper uses nanopore sequencing to study the single-nucleotide kinetics of a reverse transcriptase, revealing its ability to sense and destabilize RNA structures during cDNA synthesis.

The paper establishes a novel mouse model of persistent SARS-CoV-2 infection using Calu-3 xenografts and identifies spike protein mutations that enhance viral replication and host adaptation.

This paper introduces a STORM imaging buffer with refractive index matched to standard immersion oil, improving imaging depth and resolution for thick tissues.

The paper investigates whether haploinsufficiency from protein-null ATP1A1 variants causes disease, finding that Atp1a1+/- mice are phenotypically normal and a human with a null variant shows no disease features.

This study shows that partial in vivo reprogramming using OSKM factors induces intestinal regeneration via Ptgs1-driven prostaglandin synthesis, distinct from normal Ptgs2-dependent regeneration.

The paper identifies WNT2B and WNT7B as key ligands maintaining gastric epithelium homeostasis and shows that gastric cancer gains WNT independence through epithelial secretion of WNT7B via MAPK activation.

This study develops an inducible mismatch repair system to identify targets of orphan cytotoxins by screening for compound resistance mutations in engineered cell lines.

This paper integrates motor imagery and spatial attention paradigms for EEG-BCI control, showing improved performance over motor imagery alone in some users.

This study shows that DNMT3A-destabilizing mutations in AML increase DNA methylation heterogeneity at bivalent chromatin domains, affecting leukemic stem cell-niche interactions and drug response.

This paper introduces multifunctional ferromagnetic fiber robots capable of navigation, sensing, and treatment in minimally invasive surgery, demonstrating their use in electrophysiology sensing and localized treatment.

This paper uses deep learning to denoise STED images, reducing photobleaching and photodamage by significantly lowering pixel dwell time.

This study identifies Daam1/2 as a regulator of Wnt signaling that is essential for Paneth cell differentiation and intestinal stem cell homeostasis.

This study uses deep learning and microfluidic sorting to enrich malignant cells from body fluids, improving detection of tumor fractions and mutations.

This study identifies Mll1 as a key factor in establishing CD8+ T stem cell memory by promoting H3K4me3 deposition and regulating Pol II elongation during TCR stimulation.

The paper shows that gut bacteria can survive antibiotic treatment without developing resistance by acquiring mutations that enhance their ability to persist and invade intestinal cells.

This study evaluates the outgrowth technique for isolating epithelial cells from nasal polyps, showing high proliferation and purity.

This study shows that partial reprogramming using OSK factors in aged mice extends lifespan and improves healthspan, with potential implications for reversing age-related diseases.