J. Kim

This paper identifies EmPIM as a target for anti-AE chemotherapy and demonstrates that in silico-designed compounds can inhibit parasite growth with reduced toxicity to human cells.

This study identifies SbCYP79A61 as an enzyme in sorghum that produces phenylacetaldoxime and shows benzyl cyanide as an intermediate in its biosynthesis pathway.

This study identifies mechanisms by which Corynebacterium matruchotii enhances the fitness of adjacent Streptococcus mitis in the oral microbiome.

This study shows that reducing inositol pyrophosphates in plants increases phosphate accumulation, with potential applications for phytoremediation and sustainable agriculture.

This study identifies Pi23226, a Phytophthora effector that targets host ribosome biogenesis, inducing nucleolar stress and cell death to promote pathogenicity.

This study uses optical tweezers and FRET to identify DNA segments unwrapped during nucleosome mechanical transitions, revealing distinct low- and high-force unwrapping processes.

The paper identifies allele-specific functional differences among EGFR exon 19 deletion variants, showing how sequence and structure motifs affect oncogenic activity, dimerization, and TKI sensitivity.

This study identifies IRF3 as a key regulator of CCL22 expression in cancer cells in response to dsDNA, linking STING activation to immunosuppressive mechanisms.

The paper identifies five lung adenocarcinoma expression subtypes using consensus hierarchical clustering and finds subtype-specific dependencies on MET, CDK4, CDK6, and PD-L1, which could guide targeted therapies.

This study uses CRISPR to correct dystrophin mutations in DMD patient-derived PSCs, revealing impaired Ca2+ handling and showing rescue through gene correction.

This paper introduces a new sample delivery method for serial femtosecond crystallography, enabling reliable crystal deposition and successful structure determination of lysozyme.

The paper uses bioassays and allele characterization to analyze the introduction pathways of Spodoptera frugiperda in Asia and Australia, finding multiple introductions and resistance patterns.

This study evaluates PRKACA as a therapeutic target for fibrolamellar carcinoma using PDX models and shows that its knockdown or inhibition reduces tumor growth.

Immune checkpoint blockade therapy promotes gut microbiota translocation into secondary lymphoid organs, enhancing extraintestinal anti-tumor immunity.

This study shows L-threonine supplementation increases C. elegans healthspan by inhibiting ferroptosis via DAF-16 and HSF-1 pathways.

This study characterizes the phenotypic and genotypic features of Listeria monocytogenes isolates from Korean ruminant clinical cases, revealing genetic diversity and antimicrobial resistance.

This study identifies bypass-of-essentiality (BOE) mechanisms for Polo-like kinase (Plk) in fission yeast and human cells, revealing alternative pathways for mitotic spindle formation.

This paper introduces an imaging-guided bioreactor for de-epithelialization and long-term cultivation of ex vivo rat trachea, enabling real-time monitoring and cell replacement for bioengineered tissue applications.

This study shows that Lactococcus lactis subsp. cremoris promotes gut tissue repair via TLR2 signaling, enhancing epithelial migration and cytoprotection.

This study examines ACE-2 expression and shedding in placental tissues and maternal serum during SARS-CoV-2 infection in pregnancy, finding increased soluble ACE-2 in third-trimester infections.

This study identifies TK216 as a microtubule destabilizing agent that causes cytotoxicity in Ewing sarcoma cells, explaining its synergy with vincristine and suggesting reevaluation of its clinical trials.

This paper develops a 3D shear wave elastography technique using a 2D RCA array, demonstrating its ability to detect 3D shear wave motion and reconstruct speed maps with high volume-rate.

This study shows that cholesterol and sphingomyelin in lipid rafts are essential for Fcγ receptor-mediated phagocytosis of Cryptococcus neoformans by macrophages.

The study reports the first ancient Korean genomes from the Three Kingdoms period, revealing genetic diversity linked to northern Chinese and Japanese Jomon-related ancestry.

This study shows that Pavlovian fear conditioning does not occur in rats in naturalistic environments, while nonassociative responses to real threats do.

This study identifies HSBP as a repressor of HEI10 transcription and meiotic crossovers in Arabidopsis by binding to HSFs and maintaining DNA methylation at the HEI10 promoter.

The paper uses a transgenic mouse model to profile mitochondrial matrix proteomes and identifies RTN4IP1/OPA10 as an antioxidant NADPH oxidoreductase involved in CoQ biosynthesis and mitochondrial function.

This paper introduces MUTE-ULM, a technique that improves ultrasound localization microscopy by reducing data acquisition time through enhanced microbubble separation and localization.

This study identifies clonal hematopoiesis as an independent risk factor for severe COVID-19 in previously healthy patients, revealing distinct immunological and epigenetic signatures.