J. Song

This study uses directed evolution to identify SH2 domain variants with enhanced binding to phosphotyrosine peptides, revealing differences in cross-reactivity with sulfotyrosine.

This study shows ATP biphasically modulates TDP-43 PLD LLPS by binding arginine residues, altering physicochemical properties and aggregation behavior.

This study identifies KLHL15 as an E3 ubiquitin ligase that degrades doublecortin proteins, regulating dendritic development in neurons.

This study shows NDRG1 expression is an independent predictor of poor survival in inflammatory breast cancer patients.

This study identifies a conserved cavity in flaviviral NS2B-NS3 proteases that Curcumin binds to, allosterically inhibiting the protease by disrupting its active conformation.

This paper develops a fluorescent chemodosimeter to visualize and isolate iron-reducing microorganisms at the single-cell level, demonstrating its effectiveness in identifying active FeRM from complex samples.

The paper identifies lysine isobutyrylation as a new histone modification mark and shows its role in epigenetic regulation and cellular physiology.

This study develops a recombinant SARS-CoV-2 RBD molecule fused with a T helper epitope as an adjuvant, showing strong neutralizing antibody response in mice.

This paper validates a method to quantify aristolochic acid DNA adducts in human tissues and applies it to hepatocellular carcinoma samples, finding a low prevalence of adducts.

The paper sequenced genomes of Pneumocystis species from different mammals to study host specificity and evolutionary adaptations, revealing insights into the emergence of the human pathogen P. jirovecii.

This study identifies decorin as a negative regulator of E-cadherin in inflammatory breast cancer, showing it reduces migration, invasion, and metastasis by destabilizing E-cadherin and inhibiting EGFR/ERK signaling.

The paper identifies ANKLE1 as a nuclease that specifically cleaves branched DNA structures, suggesting its role in resolving DNA junctions during mitosis.

This study shows ATP induces protein folding, inhibits aggregation, and stabilizes proteins by mediating water-protein-ion interactions, with triphosphate being key but aggregation-prone, while ATP prevents this.

The paper investigates the ability of Arhopalus rusticus to transmit pine wood nematodes, finding that 12 beetles can transmit the nematodes through feeding on pine needles.

The paper uses computational fluid dynamics to analyze how owl tail postures affect drag during gliding, finding that observed postures minimize total drag.

This study measures wing shape and pose changes in barn owls during gliding at different speeds, finding that wing shape remains consistent while tail and posture adjustments modulate aerodynamic forces.

This study develops a novel preclinical model to assess long-term effects of precision radiation on salivary function and tissue integrity in mice.

The paper establishes a zebrafish model of G6PD deficiency that replicates key clinical features observed in humans with the condition.

This paper establishes a stable transgenic zebrafish model of G6PD deficiency that mimics clinical features and shows reduced GSH levels and G6PD abundance.

This study shows that endothelial basement membrane laminins 411 and 511 influence monocyte differentiation to macrophages by modulating migration and integrin profiles.

The paper shows that infant-directed speech and song across cultures share consistent acoustic features that can be reliably classified and are perceptible to listeners.

The paper analyzes insertion mutants in the HIV-1 gp41 C-terminal heptad repeat, finding that alanine insertion (653+A) attenuates membrane fusion due to slower 6HB formation kinetics, not 6HB stability.

This study identifies DNA deformation as a mechanism regulating DRM2-mediated methylation specificity in plants, showing how substrate deformation influences substrate preference.

This paper investigates how DHHC20 reshapes membranes to facilitate catalysis through biochemical and computational methods.

This study investigates how the feeding behavior of Monochamus alternatus affects the departure of pine wood nematodes, finding no significant difference but linking increased motility and oxidative phosphorylation to nematode departure.

This study identifies lncRNA AVAN as a positive regulator of antiviral innate immunity by interacting with TRIM25 and enhancing FOXO3a transcription.

The paper shows ATP induces protein folding, inhibits aggregation, and increases stability by combining adenosine and triphosphate.

This study develops a hydrogel platform to assemble human stem cell-derived β cells and endothelial cells into functional three-dimensional islet organoids.

The paper uses scanning transmission X-ray microscopy to identify dense granules in human platelets and reduces false detection compared to traditional TEM methods.

This study uses mass cytometry to analyze how silver nanoparticles interact with different human immune cells at the single-cell level, revealing differences in association and toxicity across cell types.