J. Wang

The paper identifies a modular (L)WY-LWY motif in Phytophthora effectors that recruits host PP2A phosphatase, enabling phosphoprotein regulation through structural mimicry.

The paper identifies an antibody with broad neutralization against SARS-CoV-2 Omicron variants and shows how somatic mutations enhance its neutralization breadth and potency.

This study evaluates how different laboratory methods affect microbiome metagenomic sequencing results through an interlaboratory comparison of 44 labs analyzing shared reference samples.

The paper shows that salt stress modulates lateral root development through an auxin-independent pathway involving ZAT6 and LBD16.

This study compares KLP-6 and UNC-104, two Caenorhabditis elegans kinesin-3 proteins, revealing that autoinhibition release triggers dimerization and processive movement in UNC-104 but not in KLP-6.

This study identifies RCAN1+IL1+ senescent synovial fibroblasts as drivers of osteoarthritis by secreting saturated fatty acids, and shows that targeting RCAN1 reduces OA progression in mice.

This study shows that Myostatin gene deletion in pigs alters gut microbiota, increasing SCFAs which stimulate fast-twitch glycolytic muscle growth through the Akt/mTOR pathway.

This paper discovers and engineers an L-threonine aldolase from Neptunomonas marine to efficiently synthesize β-hydroxy-α-amino acids with high diastereoselectivity.

The paper uses SpotLight proteomics to identify antibody sequences specific to deamidated human serum albumin, revealing insights into protein clearance and neurodegeneration prevention.

This study identifies associations between gut microbiota composition and serum metabolites with clear cell renal cell carcinoma, suggesting potential risk factors for tumorigenesis.

The paper identifies novel ATR-dependent phospho-proteomic targets and reveals new biomarkers and genome maintenance factors through screening with ATR inhibitors.

The paper develops cgSHAPE-seq to identify RNA-binding sites of coumarin derivatives targeting SARS-CoV-2 5' UTR and demonstrates their use as RNA-degrading chimeras to reduce viral RNA expression.

This study uses single-cell RNA sequencing to analyze fibroblast heterogeneity and interactions in Crohn's disease strictures, identifying CDH11 as a potential therapeutic target.

The paper studies the evolution of alternative splicing and gene duplication in a parasitoid serpin gene, finding they jointly contribute to protein diversity and show divergent evolutionary patterns.

This study identifies two coupled scale-dependent feedbacks and environmental variability as key drivers of regular redox patterns in upland soils.

The paper quantifies the role of dissolved inorganic carbon (DIC) from terrestrial organic matter decomposition in supporting aquatic food webs and highlights its significance to global carbon cycling in seasonal wetlands.

The paper identifies acetate as a novel energy stress marker produced in the liver via ACOT12/8-mediated conversion of acetyl-CoA from fatty acids, supporting its role in brain fueling and CoA recycling.

This study shows HCC-1 promotes atherosclerosis by inducing pyroptosis in endothelial cells and macrophages and suggests it as an early diagnostic biomarker.

This study constructs a nearly-complete model of the Legionella pneumophila Dot/Icm T4SS using subtomogram averaging and integrative modeling, revealing structural insights into six new components and their functional interactions.

This study improves a DNA polymerase's ability to incorporate modified nucleotides through combinatorial mutagenesis, resulting in a 20-fold efficiency gain.

This study evaluates KRASG12D inhibition in PDAC models, showing variable efficacy in 2D cultures but enhanced response in 3D cultures and xenografts, with immunological modulation contributing to tumor regression.

This study analyzes mitochondrial phylogeography of Qinghai-Tibetan Plateau grassland caterpillars, revealing speciation patterns and genetic diversity linked to geological and climatic factors.

This study shows that vaccinating with mycobacterial lipid-loaded nanoparticles induces persistent lipid antigen presence and memory T cell differentiation in mice.

This study reports cryo-EM structures of zebrafish P2X4 receptors bound to antagonists, revealing ligand-dependent structural changes that explain subtype-specific allosteric inhibition.

The paper uses multi-omics single-cell data to define the epigenetic basis of castration-resistant prostate luminal cells in mice and identifies key molecular pathways involved.

This paper develops a rapid PCR-based method to determine antimicrobial susceptibility of Neisseria gonorrhoeae using propidium monoazide and qPCR, achieving high accuracy in under 30 minutes.

This study shows that cancer-associated fibroblasts maintain ovarian cancer stem cells via noncanonical Wnt5a signaling, which contributes to chemoresistance and relapse.

The paper maps cell landscape and dynamics in rodent bone repair using single-cell RNA sequencing and identifies functional roles of myeloid and lymphoid cells in osteogenesis and angiogenesis.

The paper identifies hybrid G-quadruplexes (hG4s) in yeast cells, showing they dominate over DNA-only G4s and expand the number of G4-forming sites by over 15,000-fold.

This study characterizes the tumor microenvironment in colorectal cancer using multi-omics and spatial analysis, identifying four subtypes with distinct features and therapeutic responses.