J. Wu

This paper demonstrates a gene therapy approach using NF-κB-activated CRISPR/Cas9 to specifically target and kill cancer cells without affecting normal cells.

This study develops a CRISPR-assistant trans enhancer to efficiently activate gene expression by combining dCas9-VP64/sgRNA with a CMV enhancer.

This paper introduces laser particles for multiplexed cell tagging and imaging, demonstrating their stability, biocompatibility, and ability to track individual cells in 3D tumor models.

The paper analyzes nine red GECIs to determine the factors causing Ca2+-dependent fluorescence changes, finding three distinct classes based on their mechanisms.

This paper engineers NK cells with a recombinant Fc receptor to enhance ADCC and tumor targeting by avoiding ADAM17-mediated downregulation.

This study identifies Lsm12 as a regulator that mediates Polη deubiquitination to enhance its recruitment and improve survival under oxidative stress in yeast.

The paper shows that ATRX mutations and MYCN amplification are mutually exclusive in neuroblastoma and lead to synthetic lethality.

This study investigates how peiminine induces apoptosis in HepG2 cells through both extrinsic and intrinsic pathways, showing dose- and time-dependent effects.

This study shows that VPAC1 and TRPV4 channel interaction promotes calcium-dependent gastric cancer progression through a positive feedback loop involving VIP secretion.

This study identifies MESH1 as a cytosolic NADPH phosphatase that promotes cell survival under ferroptosis by maintaining NADPH levels and induces transcriptional changes resembling bacterial stringent response.

This study analyzes TCRB and IGH repertoires in IgAN patients to identify non-invasive biomarkers for diagnosis.

The paper quantifies nucleation in living cells using DAmFRET and shows that kinetic barriers influence prion-like phase behavior and protein aggregation.

The paper develops a gene therapy system that uses telomerase activity to kill cancer cells in mice without affecting normal cells.

This study shows that increased intermolecular interactions in antimicrobial peptides raise the energy cost to cross bacterial membranes, reducing their antibacterial activity.

This study identifies novel germline V and J alleles in Rhesus macaques by analyzing BCR repertoires and validates them using whole genome sequencing and alignment reference.

This study identifies USP7 as a key driver of T-cell leukemia by stabilizing NOTCH1 and JMJD3, showing USP7 inhibition blocks leukemia growth and suggests it as a therapeutic target.

The paper analyzes the evolution and adaptation of H7N9 influenza viruses in China, identifying lineage-specific mutations and high-pathogenicity strains.

This study shows that Hipk promotes tumorigenesis and metastatic behavior in Drosophila by enhancing proliferation, invasion, and EMT through multiple pathways.

This study examines how different Fe(III) oxides affect microbial communities and methane cycling in ferruginous sediments over time, showing that Fe(III) mineralogy influences methanogenesis and iron reduction.

The paper determines the cryo-EM structure of the human proteasome regulatory particle bound to p28, revealing its dynamic conformational landscape and role in proteasome assembly.

This study identifies AGL21 as a MADS-box transcription factor that regulates seed germination by modulating ABI5 expression in response to environmental and hormonal signals in Arabidopsis.

The paper compares selection pressures on human genes in cancer and normal cells using mutation-profile-based methods, finding differences in selection pressures and their impact on cancer gene classification.