J. Wu

This study reports the crystal structure of the N-terminal domain of DdMCU and shows its oligomeric state and calcium-dependent dissociation.

The paper integrates transcriptome and proteome data from Pseudomonas syringae in Arabidopsis to reveal gene regulation patterns influenced by plant immunity.

This study analyzes 2,152 antibody repertoires to identify key features of B cell biology, revealing gene usage patterns, sex preferences, and mutability mechanisms in the antibody repertoire.

This study assesses the vulnerability of 604 North American bird species to climate change under different warming scenarios and finds that mitigation is needed to reduce vulnerability.

This study assesses climate change risks to 544 North American bird species under two warming scenarios, finding higher risk with unmitigated warming and significant impacts from extreme weather events.

This study evaluates how adding Chinese herbal medicine residues affects antibiotic resistance genes and bacterial communities in chicken manure composting, finding increased ARG removal with higher residue addition.

The paper examines the 3D chromatin structure of mouse female germline stem cells during development, identifying changes in TADs and conserved compartments related to imprinted genes.

This paper shows overexpression of ELO2 in yeast increases complex sphingolipids, improving osmotic tolerance and cell survival under high salt conditions.

This study identifies EPRS as a key regulator of proline-rich pro-fibrotic gene translation in cardiac fibrosis, showing its role in promoting fibrosis and identifying potential therapeutic targets.

This study compares anaerobic microbial communities involved in dechlorinating different HCH isomers, identifying key bacteria and revealing shifts in community composition based on substrate.

The paper identifies a genomic region Lyb-2-4 associated with hypervirulence in carbapenem-resistant Acinetobacter baumannii, showing higher mortality in infected patients and mice.

This study shows that the PAR2 signal peptide prevents premature receptor cleavage and activation by intracellular proteases, ensuring proper cell surface expression and ligand response.

This study compares two methods for expanding human corneal endothelial cells in vitro, finding that low mitogenic conditions better preserve cell identity and that senescence occurs with continuous passaging.

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

The paper uses QTL mapping to show MHC variants bias TRBV gene usage in UCB samples, revealing germline-encoded TCR-MHC contacts influence TCR repertoire.

PIRD is a database that collects and stores annotated TCR and BCR sequencing data, along with tools for visualization and analysis.

The paper defines reference ranges for spot urine copper excretion in preschool children and identifies optimal cutoff values for pre-symptomatic Wilson’s disease screening.

This study shows HIV-1 Nef interacts with LMP7 to reduce immunoproteasome formation and MHC-I antigen presentation, aiding viral immune evasion.

This paper establishes the first reverse genetics system for a segmented negative-strand RNA plant virus, enabling molecular genetic analysis of its life cycle and pathogenicity.

This study shows STING activates the NLRP3 inflammasome by recruiting NLRP3 to the ER and deubiquitinating it, enhancing IL-1β secretion and inflammatory responses.

This study shows that BPA induces stress granules via the PERK pathway and disrupts their assembly under chronic exposure.

This paper introduces CATE-seq, a CRISPR-based targeted sequencing method that outperforms hybridization-based techniques in simplicity, specificity, sensitivity, throughput, and scalability.

This study shows that the oncoprotein CoAA interacts with RNA polymerase II CTD repeats, explaining the functional requirement of diheptad repeats in transcription and alternative splicing.

The paper compares gut metagenomics and metaproteomics in prediabetics and treatment-naïve type 2 diabetics to identify host-microbial interplays across disease stages.

The paper uses scBCR-seq to analyze B-cell repertoires and identifies antigen-reactive antibodies with high accuracy.

This study investigates DGKE deficiency in aHUS using lipidomic analysis and finds reduced PtdIns(4,5)P2, not increased DAG, is critical to the disease's pro-thrombotic phenotype.

This study identifies USP7's dual role in stabilizing EZH2 and facilitating PRC2 chromatin loading, promoting melanoma progression and correlating with poor patient prognosis.

This paper introduces a simplified CNN architecture for efficient pan-cancer whole-slide image classification and outlier detection.

This study shows that TSP4 promotes pro-inflammatory macrophage differentiation and apoptosis, with P387-TSP4 being more active in these processes.

This study identifies class I BPC proteins as regulators of FUS3 expression in Arabidopsis, showing their role in ovule development and coordination of embryo and endosperm growth.