J. Xiao

This study maps chromatin reprogramming and transcriptional regulation during hexaploid wheat embryogenesis, revealing epigenetic mechanisms governing cell fate and organogenesis.

This paper develops a spatial stochastic model to show how supercoiling affects transcription regulation in E. coli by enabling communication between RNA polymerase molecules and coordinating gene expression.

This paper develops a zebrafish xenograft model to isolate and study human breast cancer metastatic cells, identifying genes and pathways involved in invasion.

This study examines how mechanical ventilation impacts the respiratory tract microbiota in rats, finding increased biofilm formation and dispersed microbial clustering.

This study identifies how Omicron evades neutralizing antibodies by analyzing mutations and their effects on different epitope groups, showing over 85% of tested antibodies are escaped.

This study constructs a single-cell transcriptome atlas of multiple myeloma patients stratified by R-ISS, identifies PC subsets and immunotargets, and links them to prognosis and EBV infection.

This study shows that gasdermin signaling is essential for fracture healing, as its absence delays bone callus formation and reduces biomechanical properties.

This study shows FtsN activates septal peptidoglycan synthesis by forming a processive complex with FtsWI on the sPG-track, rather than displacing FtsWI from the Z-track.

This study identifies two potent monoclonal antibodies against the B.1.351 variant and shows their efficacy against other variants, suggesting their use as an antibody cocktail.

This study uses silica-dried leaf tissues for RNA-seq and phylotranscriptomic analysis, showing they are viable for phylogenomic studies with results comparable to liquid nitrogen-preserved samples.

This paper introduces SMAC, a single-molecule imaging technique that detects disease-specific proteins in blood samples at subfemtomolar concentrations.

The paper shows that Clp protease and AscarD regulate CarD levels to help mycobacteria survive starvation by reducing rRNA synthesis.

This study identifies novel SARS-CoV-2 receptors through a CRISPR activation screen, revealing LDLRAD3, TMEM30A, and CLEC4G as functional receptors independent of ACE2.

This study shows that antibiotic-induced gut microbiome disruption reduces vaccine response in mice and non-human primates, but recovery of microbiome diversity restores immune responses.

The paper presents the cryo-EM structure of Drosophila GNPTAB, revealing its catalytic domain and functional residues, and shows dimer interface importance for human GNPTAB activity.

This study develops a selective DYRK2 inhibitor, C17, and identifies novel targets like 4E-BP1 and STIM1, revealing DYRK2's role in protein synthesis and calcium entry.

This study shows that GSDME compensates for GSDMD deficiency in NLRP3 inflammasomopathy, revealing a GSDME-dependent inflammatory pathway and suggesting dual inhibition of GSDMD and GSDME for therapeutic benefit.

This study investigates the role of Rickettsia-infected endothelial cell-derived exosomes in causing barrier dysfunction in brain microvascular endothelial cells, identifying miR-23a and miR-30b as key regulators.

This study identifies two distinct processive motions of FtsW in E. coli, driven by FtsZ treadmilling or septal peptidoglycan synthesis, revealing a two-track model for sPG synthesis regulation.

This study identifies a novel mechanism where Src-mediated phosphorylation of Rpt2-Y439 regulates proteasome function at cellular membranes, impacting cancer therapy response.

This study shows EPAC1 regulates vWF secretion from endothelial cells during inflammation via the PI3K/eNOS pathway, with implications for thrombosis control.

The paper analyzes mutation spectra and compositional variability in SARS-CoV-2 clades to understand mutation patterns and their implications for viral proteomes.

This study analyzes Woesearchaeota distribution and diversity using 16S rRNA and metagenomic data, revealing their presence in host-associated environments and genomic variation across ecosystems.

This study shows FtsZ treadmilling drives directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism, controlling enzyme processivity and sPG synthesis.

The paper uses SMLM to show physiological tau oligomers on microtubules differ from pathological oligomers and links phosphorylation states to aggregate species.

This study shows that POMK phosphorylates core M3 to enable LARGE to elongate matriglycan on dystroglycan, preventing muscular dystrophy.

This study identifies LEAFY as a pioneer transcription factor in plants that licenses cell reprogramming to floral fate by displacing histones and recruiting chromatin remodelers.

This study reports cryo-EM structures of SIgA complexes, revealing their assembly mechanism and interaction with SpsA, a pneumococcal adhesin.

This study identifies an insertion sequence in SARS-CoV-2 spike protein that enhances cleavage efficiency and expands tissue tropism beyond the lungs.

This study identifies ACE2-expressing cells in the digestive system using single-cell transcriptomes, suggesting the digestive tract as a potential route for 2019-nCov infection.