J. Xu

This study compares proteomic profiles of vancomycin-intermediate resistant S. aureus strains to identify differentially expressed proteins associated with vancomycin resistance.

This paper develops PALAN MRI methods to quantify interstitial-to-cerebrospinal fluid and cerebrospinal-to-interstitial fluid flow in the brain, finding rapid interstitial fluid transit times and slower exchange from ependymal layer to parenchyma.

The paper uses single-cell transcriptomics to profile viral receptor expression in masked palm civets, identifying potential tissue tropisms for 132 viruses.

This study identifies NGF-p75 signaling as critical for coordinating skeletal cell migration during bone repair by affecting osteogenic precursor migration and bone healing.

The paper shows light-dependent cAMP synthesis controls bacterial motility via a novel photoresponsive enzyme in a soil bacterium.

This study investigates learning dynamics in larval zebrafish using a controlled light/dark preference paradigm, revealing short-term and long-term learning patterns with stimulus specificity and homeostatic control.

This study shows that SETD2 deficiency in mice worsens colonic inflammation and tumorigenesis by increasing oxidative stress and impairing epithelial barrier function.

The paper reports the structures of M. tuberculosis cytochrome bcc complexed with two anti-TB drugs, revealing binding sites and interactions that inform inhibitor design.

The paper shows that SLs in SRPS operons of Clostridium spp. evolve with specific selection pressures, revealing a link between operon stoichiometry and evolution.

This study identifies cysteine dependence in Lactobacillus iners as a therapeutic target to shift vaginal microbiota from L. iners-dominant to L. crispatus-dominant states.

This study identifies SIRT1's role in regulating sphingolipid metabolism and neural differentiation in mESCs via c-Myc and SMPDL3B, suggesting therapeutic potential for neurological diseases.

The paper identifies a new ERGIC-ERES membrane contact mediated by TMED9 and SEC12 that is essential for autophagosome biogenesis under stress.

This study characterizes global soil yeast diversity using culture-based methods and identifies environmental factors influencing their distribution.

The paper shows that soil iron levels determine whether maize benzoxazinoids promote or suppress fall armyworm growth.

The paper maps the central and peripheral projections of lung-innervating sensory neurons, identifying their targets and marker expression.

This study shows that Smad4 loss promotes lung cancer metastasis by upregulating PAK3 through miRNA regulation, suggesting Smad4 LOF as a prognostic marker and therapeutic target.

This study examines how long-term tea monoculture affects soil nutrient dynamics and bacterial communities across different stand ages.

The paper identifies genes involved in the synthesis of two distinct polysaccharides in Agrobacterium tumefaciens, essential for surface attachment.

This paper introduces a reduced graphene oxide membrane as a supporting film for cryo-EM, improving resolution and particle absorption for sub-100 kDa biomolecules.

The paper identifies PD-L1-lncRNA, a long non-coding RNA splice variant of PD-L1, that promotes lung adenocarcinoma progression by enhancing c-Myc activity.

This study identifies ZmLBD5 and ZmLBD33 as class II LBD genes in maize that regulate gibberellin and abscisic acid biosynthesis, affecting plant growth and drought tolerance.

This study identifies FFPE processing errors in oncology panel sequencing by analyzing variants from technical artifacts in FFPE samples with varying fixation times and block positions.

This study shows phosphopeptide nanofibers enable caveolae-mediated endocytosis and endosomal escape via TNAP clustering in lipid rafts.

This study identifies BIRG1 as a chloride efflux transporter in rice that regulates grain size and salt tolerance by controlling chloride homeostasis.

This study shows that IL-3 deficiency increases disease severity in mice infected with M. tuberculosis and HSV-1/HSV-2.

This paper isolates and characterizes nanobodies from camelids and engineered mice that neutralize SARS-CoV-2 variants through conserved epitopes and multimeric avidity.

This study shows SUMOylation of GMFB increases its stability and trans-localization, upregulating inflammatory pathways in RPE cells under oxidative stress and inflammation.

A natural allele of rice UMP1 promotes resistance to multiple pathogens by boosting H2O2 accumulation.

The paper analyzes T-cell receptor repertoires in different phases of COVID-19 to identify immune response patterns and predict recurrent infection risk.

This study identifies how coronavirus Nsp5 protein inhibits pyroptosis by cleaving GSDMD, preventing pore formation and viral replication inhibition.