A pathogenic missense mutation in kainate receptors elevates dendritic excitability and synaptic integration through dysregulation of SK channels
Toshihiro Nomura, Sakiko Taniguchi, Yizhi Wang, Nai-Hsing Yeh, Anika P. Wilen, Charlotte Castillon, Kendall M. Foote, Jian Xu, John N. Armstrong, Jeffrey N. Savas, Geoffrey T. Swanson, Anis Contractor
This study investigates a missense mutation in the GRIK2 gene, showing it disrupts SK channel function, leading to increased dendritic excitability and synaptic integration in hippocampal neurons.
Journal of Neuroscience · Oct 6, 2023Peer-reviewedNeuroscience