Author

L. A. Vella

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Research Focus:differential expression· 5 Assay:flow cytometry· 3 Research Focus:host-pathogen & immune response· 3 Assay:scRNA-seq· 3 Research Focus:clustering· 2

Frequent Co-Authors

E. J. Wherry· 6 shared S. Manne· 6 shared J. R. Giles· 5 shared A. E. Baxter· 4 shared J. Dougherty· 4 shared M. R. Betts· 4 shared A. Pattekar· 3 shared A. R. Greenplate· 3 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

E. J. Wherry

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Author profile →

8 papers

Recent·Most cited

Distinct Heterogeneity in the Naive T cell Compartments of Children and Adults

C. E. Gustafson, Z. Thomson, Z. He, E. Swanson, K. Henderson, M.-P. L. Pebworth, L. Y. Okada, A. T. Heubeck, C. R. Roll, V. Hernandez, M. D. Weiss, P. C. Genge, J. Reading, J. R. Giles, S. Manne, , P. J. Skene

The study identifies age-related differences in naive T cell compartments between children and adults, showing distinct molecular reprogramming in CD4 and CD8 subsets.

bioRxiv · Oct 4, 2022 · PreprintImmunology

Profound phenotypic and epigenetic heterogeneity of the HIV-1 infected CD4+ T cell reservoir

V. H. Wu, S. Nguyen, J. M. L. Nordin, J. Joy, F. Mampe, P. Tebas, L. J. Montaner, K. J. Bar, L. A. Vella, M. R. Betts

This study identifies phenotypic and epigenetic heterogeneity in the HIV-1 infected CD4+ T cell reservoir using single-cell multiomic profiling of ART-treated individuals.

bioRxiv · Apr 2, 2022Microbiology

Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19

S. A. Apostolidis, A. Sarkar, H. M. Giannini, R. R. Goel, D. Mathew, A. Suzuki, A. E. Baxter, A. R. Greenplate, C. Alanio, M. Abdel-Hakeem, D. A. Oldridge, J. R. Giles, J. E. Wu, Z. Chen, Y. J. Huang, , E. J. Wherry

This study identifies FcγRIIA and C5a-C5aR pathways as mediators of platelet hyperactivation in COVID-19 patients, showing their role in thrombotic complications.

Frontiers in Immunology · Mar 3, 2022Peer-reviewedImmunology

mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern

R. R. Goel, M. M. Painter, S. A. Apostolidis, D. Mathew, W. Meng, A. M. Rosenfeld, K. A. Lundgreen, A. Reynaldi, D. S. Khoury, A. Pattekar, S. Gouma, L. Kuri-Cervantes, P. Hicks, S. Dysinger, A. Hicks, , Set

This study shows that mRNA vaccination generates durable immune memory against SARS-CoV-2 and variants of concern, with continued evolution of B and T cell responses for at least 6 months.

bioRxiv · Aug 23, 2021 · PreprintImmunology

The identity of human tissue-emigrant CD8+ T cells

M. Buggert, L. A. Vella, S. Nguyen, V. Wu, T. Sekine, A. Perez-Potti, C. R. Maldini, S. Manne, S. Darko, A. Ransier, L. Kuri-Cervantes, A. Sada Japp, I. Bukh Brody, M. A. Ivarsson, L. Hertwig, , M. R. Betts

The paper characterizes tissue-emigrant CD8+ T cells in humans and non-human primates, revealing distinct migratory behaviors and clonal dynamics.

bioRxiv · Aug 11, 2020Immunology

Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

D. Mathew, J. R. Giles, A. E. Baxter, A. R. Greenplate, J. E. Wu, C. Alanio, D. A. Oldridge, L. Kuri-Cervantes, M. B. Pampena, K. D'Andrea, S. Manne, Z. Chen, Y. J. Huang, J. P. Reilly, A. R. Weisman, , E. J. Wherry

The paper identifies distinct immunotypes in COVID-19 patients through high-dimensional cytometry, linking them to disease severity and potential therapeutic implications.

bioRxiv · May 20, 2020Immunology

Chronic viral infection promotes early germinal center exit of B cells and impaired antibody development.

R. P. Staupe, L. A. Vella, S. Manne, J. R. Giles, W. Meng, R. S. Herati, O. Khan, J. E. Wu, A. E. Baxter, E. T. Luning Prak, E. J. Wherry

This study shows chronic viral infection disrupts GC B cell fate decisions, leading to early exit and impaired antibody development.

bioRxiv · Nov 21, 2019 · PreprintImmunology

Vaccine-induced ICOS+CD38+ cTfh are sensitive biosensors of age-related changes in inflammatory pathways

R. S. Herati, L. V. Silva, L. A. Vella, A. Muselman, C. Alanio, B. Bengsch, R. Kurupati, S. Kannan, S. Manne, A. Kossenkov, D. Canaday, S. Doyle, H. Ertl, K. Schmader, E. J. Wherry

The paper uses transcriptional profiling to show that vaccine-induced ICOS+CD38+ cTfh cells in elderly show inflammation-related gene signatures and age-associated biological changes.

bioRxiv · Jul 24, 2019 · PreprintImmunology