K. Tomita

Downregulation of Semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis

This study shows that downregulation of Sema4A in keratinocytes is associated with non-lesional psoriasis features and that Sema4A regulates skin homeostasis and inflammation.

The highly developed symbiotic system between the solar-powered nudibranch Pteraeolidia semperi and Symbiodiniacean algae

This study examines the symbiotic relationship between the nudibranch Pteraeolidia semperi and Symbiodiniacean algae, revealing its complex structure and bleaching processes.

SARS-CoV-2 Omicron spike H655Y mutation is responsible for enhancement of the endosomal entry pathway and reduction of cell surface entry pathway

This paper investigates how the H655Y mutation in the Omicron SARS-CoV-2 spike protein enhances endosomal entry and reduces cell surface entry, altering viral tropism and fusogenicity.

Metalloproteinase-dependent and TMPRSS2-independnt cell surface entry pathway of SARS-CoV-2 requires the furin-cleavage site and the S2 domain of spike protein

This study identifies a TMPRSS2-independent metalloproteinase-dependent entry pathway for SARS-CoV-2 that requires the furin cleavage site and S2 domain of the spike protein, highlighting new therapeutic targets.

Skeletal muscle releases extracellular vesicles with distinct protein and miRNA signatures that accumulate and function within the muscle microenvironment

This study identifies markers for skeletal muscle-derived extracellular vesicles (SkM-EVs) and shows they mainly function within the muscle microenvironment rather than contributing significantly to plasma EVs.

Selective Elimination of Osteosarcoma Cell Lines with Short Telomeres by ATR Inhibitors

This study identifies that osteosarcoma cell lines with short telomeres are selectively sensitive to ATR inhibitors, suggesting telomere length as a predictor of drug response.

Emergence of a novel interaction between brown bear and cicada due to anthropogenic habitat modification

The paper shows that anthropogenic habitat modification leads to a novel predator-prey interaction between brown bears and cicada nymphs.