Longitudinal assessment of DREADD expression and efficacy in the monkey brain
Yuji Nagai, Yukiko Hori, Ken-ichi Inoue, Toshiyuki Hirabayashi, Koki Mimura, Kei Oyama, Naohisa Miyakawa, Yuki Hori, Haruhiko Iwaoki, Katsushi Kumata, Ming-Rong Zhang, Masahiko Takada, Makoto Higuchi, Takafumi Minamimoto
This study longitudinally assesses DREADD expression and efficacy in macaque monkeys using PET imaging and functional studies, showing peak expression at 60 days and sustained effects for two years.
eLife · Oct 22, 2025Peer-reviewedNeuroscience