L. Gao

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

The paper investigates how AKR1C and NADH contribute to cis-platin resistance in HepG2 cells using transcriptomic and metabolic analysis.

This paper introduces photoswitchable epothilone reagents (STEpos) that allow optical control over microtubule stability and dynamics with high spatiotemporal precision.

This paper introduces two new photoswitchable reagents for in vivo control of microtubule dynamics and related processes, showing their effectiveness in 3D systems and model organisms.

This paper identifies Rab5a as a host factor that RSV activates to suppress IRF1-dependent IFN-λ production, thereby reducing antiviral immunity in airway epithelial cells.

This study examines how broccoli sprout sulforaphane affects hemodynamics and aortic myogenic contractions in mice consuming saline water.

This study develops a 3D airway epithelial ALI model to study coronavirus infection and drug efficacy, finding it mirrors human airway responses and drug effects.

This study identifies age and ethnicity-specific gene expression biomarkers for immune aging using transcriptomic data from peripheral blood mononuclear cells.

The paper sequences 242 Ae. tauschii accessions to study genetic diversity in the bread wheat D-subgenome, identifies disease resistance genes, and demonstrates their functional transfer into wheat.

The paper identifies HLA-A2 restricted T cell epitopes in SARS-CoV-2 spike protein and finds that variations in these epitopes may reduce T cell activation and contribute to immune escape.

This study shows that DSS-induced colitis in mice damages colonic crypts, leading to reduced smooth muscle tension and impaired myogenic contractions.

This study shows ASIC1a contributes to cardiac ischemia-reperfusion injury and that inhibiting it protects heart function, with genetic variants linked to myocardial infarction.

This study uses pH-sensitive fluorescent protein to track vacuolar pH changes during cell-in-cell mediated death, revealing distinct pH dynamics in entotic and apoptotic death and their implications for cancer treatment.

The paper constructs and validates a prognostic signature for prostate cancer using ferroptosis-related genes, showing its association with clinical outcomes and therapeutic response.

This study identifies structural variants in Brassica oleracea genomes that contribute to morphological divergence between cauliflower and cabbage.

This study systematically analyzes peroxiredoxins (PRDXs) across 33 cancer types, examining expression, genetic alterations, methylation, prognosis, pathways, and drug targets, with validation of PRDX6's role in bladder cancer cell proliferation via JAK2-STAT3 pathway.

This paper introduces ultrafast contour imaging to improve resolution in time-domain diffuse optical tomography by enabling efficient light collection over curved surfaces.

This study shows that exogenous calcium is toxic to fungal cells lacking calcineurin, a key calcium regulator, and that this toxicity is linked to cytosolic calcium overload and vacuolar storage deficits.

The paper designs ACE2-Fc variants with lost enzymatic activity but retained antiviral function to avoid cardiovascular side effects.

This paper introduces compressed FLIM for high-speed, high-resolution live-cell imaging, achieving 100 Hz imaging with reduced photobleaching and motion artifacts.

This study designs excretable AIE dots for deep-tissue imaging in marmosets, demonstrating their biocompatibility and excretion capabilities.

The paper introduces a tiling light sheet microscope capable of rapid multicolor 3D imaging of cleared tissues with adjustable spatial resolution and alignment through phase modulation.

A 573 bp insertion in the YFT1 gene's 5' UTR disrupts ethylene signaling and carotenoid synthesis, causing yellow fruit in tomato mutants.

This paper identifies and characterizes ittA, an intergenic sRNA in Borrelia burgdorferi, showing its role in infectivity and tissue tropism through genetic inactivation and transcriptomic/proteomic analyses.

This paper describes an open-source bottom-illuminated orbital shaker for microalgae cultivation, offering consistent light intensity and low cost.

The paper uses protein-proofed single-cell RNA profiling to identify tissue cells vulnerable to SARS-CoV-2 infection across 36 tissues, revealing lung and cardiac cells as top targets.

This study identifies AfRip3 as a key modulator of necroptotic death in A. fumigatus, showing it is induced by Ca2+ and activates JNK and SMase pathways.

The paper shows dietary glucose promotes Plasmodium infection by expanding a gut bacterium that alkalizes mosquito midgut, enhancing parasite development.

The paper identifies a p53-dependent process called mintosis that eliminates aneuploid mitotic progenies through entosis to counteract genome instability.