L. Luo

This paper introduces a noninvasive optical coherence elastography method to profile cell and tissue mechanical properties using ambient vibrations, validated in silico and in vitro.

This study examines the kinetic response of B-cell receptor (BCR) repertoire diversity and lineage expansion in non-human primates after TLR7/8 stimulation, finding that TLR7/8 selectively expands high-mutation, low-frequency IgKL lineages.

This study shows that TLR9 signaling in microglia occurs in macropinosomes, which regulate inflammatory responses through co-receptors and regulators.

This study develops sPLA2 inhibitor-loaded micellar nanoparticles that reduce inflammation and slow osteoarthritis progression in human and mouse models.

The paper generates a single-cell atlas of pig lung using scRNA-seq and develops an online platform to explore lung single-cell data across species.

This study identifies amilorides as small molecules that inhibit SARS-CoV-2 replication by targeting conserved RNA structures in the 5-UTR region.

This study shows early high-fat diets increase mammary cancer risk by epigenetically boosting IGF1, which expands mammary stem cells and promotes carcinogen-induced tumors.

This study shows that deleting Atm in p53-deficient brainstem gliomas enhances radiosensitivity, while p53 wild-type tumors respond to radiotherapy regardless of Atm status.

This study identifies Notch1 activation as a key driver of radiation-induced thymic lymphoma in p53 wild-type mice through genomic and functional analyses.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

This study quantifies the Zn uptake and distribution requirements needed to achieve high grain Zn concentration in high-yield wheat on low-Zn calcareous soils.

The paper compares immune landscapes in transplant and primary tumors after immunotherapy and radiotherapy, finding that transplant tumors respond better due to CD8+ T cell enrichment.

This study profiles single-cell epigenomic and transcriptomic data from Parkinson's disease mouse brain to identify early biomarkers and cellular contributions to disease pathology.

PIRD is a database that collects and stores annotated TCR and BCR sequencing data, along with tools for visualization and analysis.

This study shows that APOL1-G0 protects podocytes from HIV-induced damage in mice, while APOL1-G2 does not provide similar protection.