Tessa Kole

A repair-associated bronchial epithelial differentiation trajectory through KRT14+ basal and hillock-like cells drives airway inflammation and remodelling in childhood-onset asthma

The paper identifies a novel asthma-associated epithelial differentiation trajectory involving KRT14+ basal cells and hillock-like cells that contributes to airway inflammation and remodelling in childhood-onset asthma.

Type VI collagen is proportionally lower around airways and blood vessels in idiopathic pulmonary fibrosis

The paper shows that in IPF lungs, COL6 gene expression is higher but protein levels and synthesis around airways and vessels are lower, suggesting disrupted matrix organization and fibroblast persistence.

FixNCut: Single-cell genomics through reversible tissue fixation and dissociation

FixNCut is a reversible fixation and dissociation method that preserves RNA integrity and cellular composition in human and mouse tissues, enabling robust single-cell and spatial analyses.

Airway epithelial response to RSV is impaired in multiciliated and goblet cells in asthma

This study examines the RSV response in bronchial epithelial cells from asthma patients and healthy donors, finding impaired antiviral responses in goblet and multiciliated cells in asthma.