EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis
S. Chakraborty, A. M. Bhat, I. Mushtaq, H. Luan, A. Kalluchi, S. Mirza, M. D. Storck, N. Chaturvedi, J. A. Lopez-Guerrero, A. Llombart-Bosch, I. Machado, K. Scotlandi, J. L. Meza, G. Ghosal, D. W. Coulter, , H. Band
This study shows EHD1 promotes Ewing sarcoma by regulating IGF-1R trafficking to the cell surface, which is essential for tumor growth and metastasis.
bioRxiv · Jan 15, 2023Cancer Biology