This study identifies GFPT2 as a metabolic checkpoint in EGFR-mutated NSCLC that promotes immune evasion, and shows that targeting GFPT2 enhances PD-1 blockade therapy.

bioRxiv · Mar 1, 2024 · PreprintCancer Biology

The discovery of antimicrobial peptides from the gut microbiome of cockroach Blattella germanica using deep learning pipeline

S. Chen, H. Qi, X. Zhu, T. Liu, Y. Teng, Q. Gong, C. Jia, T. Liu

The paper develops a deep learning pipeline to identify antimicrobial peptides from the gut microbiome of Blattella germanica, finding two AMPs with low toxicity and antimicrobial activity.

bioRxiv · Feb 12, 2024Microbiology

PALMO: a comprehensive platform for analyzing longitudinal multi-omics data

S. V. Vasaikar, A. K. Savage, Q. Gong, E. Swanson, A. Talla, C. Lord, A. Heubeck, J. Reading, L. T. Graybuck, P. Meijer, T. R. Torgerson, P. Skene, T. Bumol, X.-j. Li

PALMO analyzes longitudinal multi-omics data by decomposing variations, identifying stable/variable features, and detecting markers across timepoints, validated on a complex dataset and external benchmarks.

bioRxiv · Oct 17, 2022 · PreprintImmunology

The brown algae Saccharina japonica and Sargassum horneri exhibit species-specific responses to synergistic stress of ocean acidification and eutrophication

Y. Liu, J. Cao, Y. Chu, Y. Liu, Q. Wang, Q. Gong, J. Li

This study examines how Saccharina japonica and Sargassum horneri respond to ocean acidification and eutrophication, finding that S. horneri has competitive advantages under combined stress.

bioRxiv · Mar 15, 2021Ecology

Microfluidic Device Facilitates Novel In Vitro Modeling of Human Neonatal Necrotizing Enterocolitis-on-a-Chip

W. E. Lanik, C. J. Luke, L. S. Nolan, Q. Gong, J. M. Rimer, S. E. Gale, R. Luc, S. S. Bidani, C. A. Sibald, A. N. Lewis, B. Mihi, P. Agrawal, M. Goree, M. Maestas, E. Hu, , M. Good

The paper introduces a microfluidic model of human neonatal small intestinal epithelium to study NEC, showing inflammation, barrier disruption, and epithelial dysfunction.

bioRxiv · Nov 29, 2020Cell Biology

Structural and biochemical mechanisms of NLRP1 inhibition by DPP9

M. Huang, X. Zhang, T. G. Ann, Q. Gong, J. Wang, Z. Han, B. Wu, F. L. Zhong, J. Chai

This study identifies the structural and biochemical mechanism by which DPP9 inhibits NLRP1, preventing its activation and maintaining it in an auto-inhibited state.

bioRxiv · Aug 13, 2020Immunology

Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8

Q. Gong, K. Robinson, C. Xu, J. Zhang, Z. Z. Boo, D. E. T. Teo, Y. Zhang, J. S. Y. Lim, W. I. Goh, G. Wright, F. L. Zhong, B. Wu, B. Reversade

This study reveals the structural mechanisms by which NLRP1 and CARD8 assemble distinct inflammasome complexes through unique CARD domain interactions.

bioRxiv · Jun 17, 2020Immunology

Similar gut bacterial microbiota in two fruit-feeding moth pests collected from different host species and locations

Q. Gong, L.-J. Cao, J.-C. Chen, Y.-J. Gong, D.-Q. Pu, Q. Huang, A. A. Hoffmann, S.-J. Wei

This study compares gut bacterial microbiota of two fruit-feeding moths from different host plants and locations, finding shared bacterial genera and stability within species despite dietary variation.

bioRxiv · Apr 6, 2020Microbiology

MITA couples with PI3K to regulate actin reorganization during BCR activation

C. Liu, Y. Jing, D. Kang, L. Yang, P. Jiang, N. Li, J. Cheng, J. Li, H. Miller, B. Ren, Q. Gong, W. Yin, Z. Liu, P. Mattila, B. Yu

This study shows MITA regulates BCR signaling through actin reorganization via the PI3K pathway, affecting B cell differentiation and autoimmune disease.

bioRxiv · Jun 15, 2018Immunology