P. Ghosh

This study shows GIV/Girdin regulates spatiotemporal signaling during sperm capacitation and is essential for male fertility by modulating distinct signaling programs in sperm tail and head.

The paper shows that SPT6 loss in keratinocytes leads to transdifferentiation into an intestinal fate, mimicking Barrett's metaplasia and linking acid exposure to metaplastic progression.

The paper identifies shared and divergent immune pathways in MIS-C and Kawasaki disease using gene signatures and clinical data.

This study compares the antioxidant and antibacterial activities of different extract fractions from Callistemon citrinus leaves, finding the aqueous fraction has highest antioxidant activity while petroleum ether has highest antibacterial activity.

This study investigates the role of autophagy in monocyte to macrophage differentiation, showing its critical role in sustaining the process and directing differentiation via protein degradation.

This paper investigates how a short synthetic β-peptide forms transmembrane pores in lipid bilayers through molecular dynamics simulations, showing sequence-dependent pore formation and membrane disruption.

This study uses simulations to show that bacterial swarming speed and vorticity depend non-monotonically on cell aspect ratio due to size-dependent motility forces and mechanical interactions.

This study investigates the hypoglycaemic effect of Manilkara hexandra leaf extract on glucose metabolism in Labeo rohita fingerlings by analyzing enzyme activities and serum glucose levels.

This study shows clerodin induces mitotic abnormalities, G2/M arrest, and polyploidy in cells, similar to colchicine, through microtubule destabilization and shared binding site interaction.

This study develops a human lung organoid model to emulate COVID-19 pathogenesis, showing proximal airway cells drive viral infection while distal cells drive excessive immune response.

This paper develops and characterizes an mRNA-LNP vaccine candidate targeting the D614G variant of SARS-CoV-2, showing neutralizing antibody and balanced cellular immune responses in preclinical trials.

The paper examines the evolutionary changes in GIV/Girdin's modularity, interactome, and functions across invertebrates and vertebrates, revealing distinct roles in cancer as tumor suppressor or oncogene.

This study shows that Chromogranin A regulates gut permeability through the opposing actions of its proteolytic peptides CST and PST.

This paper models a signaling circuit with dual GTPase species and identifies how coupling and feedback loops affect stability and steady-state behavior.

This study shows GIV/Girdin dampens TLR4-mediated inflammatory responses in macrophages by inhibiting receptor dimerization and downstream signaling.

This study identifies how receptor tyrosine kinases activate heterotrimeric G proteins through phosphorylation of Gi's interdomain cleft tyrosines, revealing a tyrosine-based signaling mechanism with implications in cancer.

This study shows that chronic e-cigarette use damages the gut barrier and causes inflammation, driven by non-nicotine chemicals in e-liquids.

This study shows that NEIL2, a DNA repair enzyme, is downregulated by Fusobacterium infection, leading to DNA damage and inflammation in colonic epithelial cells, and this effect is specific to microsatellite stable colorectal cancers.

This study shows that CST reduces hypertension and cardiac inflammation by suppressing macrophage activity in mice.

This study identifies key determinants of adenine-mutagenesis in a DGR system by analyzing the catalytic efficiency of the bRT-Avd complex.

This study identifies DDX5 as a regulator of tissue-specific oncogenic RNAs in intestinal tumorigenesis, showing its role in promoting colon and small intestine cancers.

This paper shows that GIV binds Kindlin-2 to enhance integrin activation, promoting cell adhesion and invasion, and links this interaction to metastasis in tumor transcriptomics.

This paper identifies GIV/Girdin as the mammalian homolog of yeast Bem1p, showing it binds Exo70 and is essential for polarized exocytosis, matrix metalloprotease delivery, and cell invasion.

The paper shows that tyrosine phosphorylation regulates Daple-PARD3 complex assembly at cell-cell junctions, influencing planar cell polarity during migration.

The paper identifies FCER1G and TYROBP as universal macrophage biomarkers using the BECC computational approach, validated across human and mouse tissues.

This study shows that NEIL2 suppression by H. pylori infection leads to DNA damage accumulation, inflammation, and gastric cancer progression in mouse models and human cells.

This paper uses a game theoretic framework based on Nash equilibria to model and simulate competing pathways of amyloid-β aggregation in the presence of fatty acids, showing how rate constants control oligomer formation.

The paper reports the crystal structure of a thermostable DGR variable protein from Thermus aquaticus and confirms its CLec-fold structure, supporting its potential for molecular display applications.

The paper demonstrates that the DGR reverse transcriptase and Avd protein complex selectively mutagenize adenines during cDNA synthesis from DGR RNA templates.

The paper shows that Daple transcript isoforms V1 and V2 in peripheral blood predict melanoma prognosis, with V2 improving survival and V1 worsening it.