R. Huang

This study shows berberine reverses multidrug resistance in Candida albicans by hijacking the Mdr1p efflux pump for drug import, leading to mitochondrial dysfunction and selective cell death.

This study investigates how plant and rhizobial genotypes influence the transcriptional response of rhizobia during the initiation of plant-rhizobium symbiosis, finding significant genotype x genotype interactions.

This study uses single-cell RNA sequencing to analyze gastric cancer tumor microenvironment, identifying reprogramming in immune and stromal cells and novel molecular targets for immunotherapy.

The paper examines how intestinal inflammation affects ACE2 and TMPRSS2 expression and identifies shared molecular networks between COVID-19 and IBD.

This study examines bisubstrate analog interactions with NTMT1 to understand active site plasticity and identifies a 4-C linker analog as the most potent inhibitor.

This paper designs and characterizes peptidomimetic inhibitors of NTMT1/2, showing high selectivity and cell-permeable activity.

The paper develops a fluorescence polarization-based competition assay to identify NNMT inhibitors, capable of detecting both direct and allosteric inhibitors with high robustness.

The paper identifies the proteasome as critical for ZIKV and DENV replication through three systems biology approaches and finds proteasome inhibitors suppress both viruses.

This study compares transcriptional responses to oncogenes in cancer-resistant and -prone species, finding that naked mole rat cells resist Ras-induced changes due to dampened PI3K/AKT signaling.

This study identifies YSL3-mediated copper transport as critical for fertility, grain yield, and size in Brachypodium, with implications for improving crop production in copper-deficient soils.

This study investigates how CXCL12 affects human sperm motility and chemotaxis through its receptors CXCR4 and CXCR7, finding CXCR4 is the dominant mediator.

This study shows that CHL1 overexpression reverses chemoresistance to cisplatin and paclitaxel in lung cancer by inhibiting the Akt pathway.

This study identifies a Clostridia-rich microbiota as a contributor to excessive bile acid excretion in IBS-D patients through metagenomic and metabolomic analyses.

This study identifies OsCYP71D8L as a regulator of gibberellin and cytokinin homeostasis in rice, affecting growth and stress tolerance.

The paper examines factors influencing gut microbiota density across mammals, disease states, and interventions, finding host and microbial factors shape density and impact health.

This study examines transcriptomic changes in the diatom Phaeodactylum tricornutum under elevated pCO2, finding down-regulation of chromatin structure genes and up-regulation of histone acetylation enzymes and transposable elements.

This study identifies a bacterial community YFMCD4 that effectively removes microcystin-LR from water, with degradation rates influenced by temperature, pH, and concentration.

This paper develops an inducible CRISPR-ON system to controllably activate genes in human pluripotent stem cells, demonstrating its ability to regulate NANOG expression and enhance cell survival and integration with mouse blastocysts.

The paper captures the structure of VAT, an AAA+ unfoldase, during substrate unfolding using cryo-EM, revealing a hand-over-hand mechanism.