Author

L. Balasubramaniam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 3 Research Focus:development & morphogenesis· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

B. Ladoux· 4 shared A. S. Yap· 2 shared R.-M. Mege· 2 shared S. Sonam· 2 shared Y. Toyama· 2 shared A. Doostmohammadi· 1 shared A. Lapierre· 1 shared A. Maitra· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersCell Biology

B. Ladoux

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Aging and freezing of active nematic dynamics of cancer-associated fibroblasts by fibronectin matrix remodeling

C. Jacques, L. Perrin, J. Ackermann, S. Bell, O. Zajac, A. Lapierre, L. Anger, C. Hallopeau, C. Perez-Gonzalez, L. Balasubramaniam, X. Trepat, B. Ladoux, A. Maitra, R. Voituriez, D. Matic Vignjevic

This study investigates how fibronectin matrix remodeling by cancer-associated fibroblasts (CAFs) influences their nematic dynamics, revealing aging and freezing of defect motion in the ECM.

bioRxiv · Nov 22, 2023Cell Biology

Mechanical stress driven by rigidity sensing governs epithelial stability

S. Sonam, L. Balasubramaniam, S.-Z. Lin, I. Yow, I. P. Jauma, C. Jebane, M. Karnat, Y. Toyama, P. Marcq, J. Prost, R.-M. Mege, J.-F. Rupprecht, B. Ladoux

The paper shows that substrate stiffness drives mechanical switches in epithelial monolayers, leading to stochastic failure through topological defects.

bioRxiv · Mar 10, 2022Biophysics

Nature of active forces in tissues: how contractile cells can form extensile monolayers

L. Balasubramaniam, A. Doostmohammadi, T. B. Saw, G. Sankara, R. Mueller, T. Dang, M. Thomas, S. Gupta, S. Sonam, A. S. Yap, Y. Toyama, R.-M. Mege, J. Yeomans, B. Ladoux

The paper investigates how epithelial cell monolayers switch from extensile to contractile behavior as intercellular contacts weaken, revealing mechanotransductive responses and implications for cell sorting and tissue dynamics.

bioRxiv · Oct 28, 2020Biophysics

Caveolae set levels of epithelial monolayer tension to eliminate tumor cells

J. L. C. Teo, G. A. Gomez, I. Noordstra, S. Verma, V. Tomatis, B. R. Acharya, L. Balasubramaniam, H. Katsuno-Kambe, R. Templin, K.-A. McMahon, R. J. Ju, S. J. Stebhens, B. Ladoux, R. G. Parton, A. S. Yap

The paper shows caveolae regulate epithelial tension through lipid signaling, enabling the elimination of oncogene-transformed cells by apical extrusion.

bioRxiv · May 9, 2019 · PreprintCell Biology