S. Dutta

This study reveals the activation mechanism of the human Smoothened receptor using molecular dynamics simulations, showing a stage-wise movement of transmembrane helices and a hydrophobic tunnel for cholesterol transport.

This paper investigates how two LMNA mutations, R453W and W514R, affect lamin A structure, epigenetic regulation, and gene expression in muscular dystrophy.

The paper evaluates clustering algorithms for time-series lumbar and pelvis kinematic data, finding that multiple evaluation methods are needed to determine the optimal number of clusters and algorithm.

This study identifies a thermophilic strain SMMA_5, a phylogenetic relative of Paracoccus, capable of surviving high temperatures and shows how thermal conditioning and environmental solutes enhance its thermal endurance.

This study evaluates local potato cultivars from North Bengal for morphology and anthocyanin content to identify stable genotypes with high tuber yield and antioxidant properties.

The paper investigates molecular regulators in LMNA-related muscular dystrophy using genome-wide expression analysis in murine muscle cells, identifying dysregulated pathways and gene networks.

This study identifies BrnQ-type branched-chain amino acid transporters as critical for B. anthracis growth and virulence, showing that exogenous BCAAs are necessary for optimal growth and that transporter deletion reduces virulence in mice.

The paper identifies CD36 homologs as conserved lipid receptors mediating anti-Borrelia immunity in both ticks and humans.

This study evaluates how lamin A/C mechanotransduction is affected by surface topography in LMNA-related muscular dystrophy, finding altered cell and nuclear morphology and gene expression patterns in mutant cells.

This study shows an engineered ACE2 peptide effectively mitigates ARDS and death in mice infected with multiple SARS-CoV-2 variants.

The paper shows that telomere length modulates IL1R1 expression via TRF2 binding, affecting immune signaling and macrophage infiltration in TNBC.

This study investigates how PDZ domains in HtrA2 subunits synergistically regulate allosteric activation through inter-subunit crosstalk, revealing a model of cooperative energy landscape dynamics.

This study examines how tectonic and climatic changes during the Oligo-Miocene affected bivalve fauna in the Kutch Basin, finding limited faunal exchange and stable diversity patterns.

This study shows that rotenone treatment causes early NAD+ loss, leading to Sarm1 activation, which is prevented by PARP inhibition in both cell cultures and Drosophila.

This study examines how co-infections with Plasmodium falciparum and helminths affect antibody responses in Mozambican individuals, finding increased IgE and IgG levels in co-infected individuals.

This study investigates the molecular mechanism of partial agonism in cannabinoid receptors, finding that THC stabilizes both agonist and antagonist-like poses through its alkyl side chain, leading to partial receptor activation.

This study examines how past logging and ongoing anthropogenic disturbances affect vegetation in Himalayan Foothills, finding that selective logging promotes secondary forest features but CAD reduces native diversity and facilitates invasions.

This study uses molecular dynamics simulations to investigate Na+ binding mechanisms in cannabinoid receptors CB1 and CB2, identifying distinct binding sites and pathways.

This study compares the immunogenicity of soluble trimeric influenza stem domain immunogens and nanoparticle-displayed versions, showing similar protection against homologous and heterologous viral challenges.

This study investigates the hypoglycaemic effect of Manilkara hexandra leaf extract on glucose metabolism in Labeo rohita fingerlings by analyzing enzyme activities and serum glucose levels.

This study designs a thermotolerant trimeric RBD vaccine candidate that elicits strong neutralizing antibodies against multiple SARS-CoV-2 variants in animal models.

This study examines how land-use changes affect bird communities in the Western Thar Desert, finding that protected grasslands support higher bird diversity and specialists, while croplands and rangelands negatively impact specialists.

This study identifies Hmrhl as a regulator of cancer-related genes in CML through chromatin association and functional experiments.

This paper designs a thermotolerant, immunogenic SARS-CoV-2 RBD protein fragment that is stable at high temperatures and elicits neutralizing antibodies in guinea pigs.

This study analyzes SARS-CoV-2 genomic diversity in India, identifying 33 mutations and classifying strains into 22 groups based on co-existing mutations.

The paper shows that bromelain peptides from pineapple inhibit Aβ fibrillation and dissociate preformed fibrils, reducing their cytotoxicity in cells and animal models.

This paper demonstrates magnetoelectric materials enable miniature, wireless neural stimulators operating at therapeutic high-frequencies for treating Parkinson's disease in rodents.

This study shows that Atf-6 extends lifespan in C. elegans by modulating ER-mitochondrial calcium homeostasis and signaling.