S. Hu

This study identifies bosutinib as a radiosensitizer for breast cancer by targeting eIF4G1, enhancing radiation efficacy and reducing drug dosage.

This study designs, synthesizes, and evaluates two peptidomimetic aldehydes as antiviral drug candidates targeting SARS-CoV-2 main protease, showing potent inhibition and anti-infection activity.

This paper introduces MorphEUS, a morphological profiling method that classifies drugs based on their effects on Mycobacterium tuberculosis morphology, identifying both primary and off-target pathways of action.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This study develops a recombinant ACE2-Ig fusion protein that neutralizes both SARS-CoV and 2019-nCoV in vitro, showing cross-reactivity and potential for diagnostic, prophylactic, and therapeutic applications.

This study identifies Blimp-1 as a positive regulator of Th2 cell development and allergic asthma through an IL-10-STAT3-Blimp-1 circuit.

The paper shows TIGIT-Fc promotes immune tolerance at the feto-maternal interface by enhancing IL-10 production and TH2 polarization in decidual CD4+ T cells, and increasing pregnancy rates in stressed mice.

The paper identifies enhancers and microRNAs as drivers of cell state variation in embryonic stem cells, showing how they form feedback loops to generate new cell states.

This study shows that TIGIT-Ig treatment delays lupus onset, reduces autoantibodies, and improves survival in mice, suggesting potential for human autoimmune disease therapy.

This study shows that delivering a RyR2-targeting nanobody via AAV9 improves cardiac function in rat models of ischemic heart failure by reducing calcium leak and reversing dysfunction.

This study investigates how forces affect filopodia adhesion, showing that myosin IIA and formins are essential for force-dependent adhesion and substrate preference.

This study shows that deleting the ycgN gene in B. licheniformis increases gamma-PGA synthesis by raising intracellular ROS levels through P5C accumulation.

This study shows HBV inhibits neutrophil extracellular traps (NETs) release by reducing reactive oxygen species (ROS) and autophagy, contributing to chronic infection.

This study identifies the molecular mechanisms and post-translational modifications governing the generation of distinct Nrf1α/TCF11 proteoforms and their involvement in feedback circuits with regulatory proteins.

This study shows myricetin reduces inflammation in LPS-induced RAW 264.7 macrophages and mouse models of acute lung injury by inhibiting NF-κB and MAPK pathways.

This study identifies topovectorial mechanisms that control Nrf1 proteolytic processing to generate mature CNC-bZIP transcription factor isoforms through ER-associated degradation.

This study shows that Helicobacter pylori uses chemotaxis to overcome host-generated reactive oxygen species, enabling colonization of stomach glands.