S. Roy

The paper uses intravital imaging to show macrophage-induced cancer stem cells (CSCs) are enriched at TMEM doorways during metastasis, with CSCs comprising >60% of circulating tumor cells.

This paper develops a scalable platform for producing SARS-CoV-2 spike protein pseudotyped MLV-like particles, showing efficient incorporation of a truncated spike protein into VLPs.

This study shows that mutations in two FANC genes in mice model the severity and heterogeneity of Fanconi Anemia, revealing functional synergism of polygenic mutations.

This study identifies how receptor tyrosine kinases activate heterotrimeric G proteins through phosphorylation of Gi's interdomain cleft tyrosines, revealing a tyrosine-based signaling mechanism with implications in cancer.

This paper analyzes the dynamics of COVID-19 related publications across PubMed, Elsevier, and ResearchGate, finding rapid growth in publication rates and geographic author distribution.

This study shows that γH2AX peaks in S phase after UV irradiation due to replication activity, not DNA damage extent, and cells complete replication before arresting in G2.

The paper investigates denitrification kinetics and nitrous oxide (N2O) accumulation in Accumulibacter under different electron acceptor conditions, finding no effect of electron competition on N2O uptake.

This study identifies a dynamic conformational asymmetry in the 2019-nCoV spike protein that enhances its infectivity by enabling rapid recognition of host-cell receptors.

The paper reconstructs gene regulatory networks in cichlids to study GRN evolution linked to adaptive traits, identifying regulatory variants and network rewiring in visual opsin genes.

This study surveys the conservation community to assess their access to scientific literature, finding that about half struggle with access despite high demand.

The paper detects the mcr-1 gene in Salmonella isolates from poultry in Bangladesh using PCR and bioinformatics analysis, revealing colistin resistance mechanisms.

This study shows that the Leishmania Donovani protein KMP-11 induces membrane phase transition in macrophages, facilitating infection by altering membrane tension and lipid raft structure.

This study models the emergence of ribozyme and tRNA-like structures from prebiotic environments through non-enzymatic polymerization and hydrolysis processes.

The paper identifies QTLs associated with grain yield and related traits in rice using SSR markers and association analysis.

This paper shows that GIV binds Kindlin-2 to enhance integrin activation, promoting cell adhesion and invasion, and links this interaction to metastasis in tumor transcriptomics.

This paper identifies an allosteric hot-spot in ZAP-70's tandem-SH2 domain that regulates T-cell signaling by enabling cooperative ligand binding, with mutations disrupting this process and causing autoimmune arthritis.

The paper maps pregnenolone interactomes in cancer and immune cells using chemical biology and chemoproteomics to identify proteins involved in its trafficking and non-genomic actions.

The paper introduces a polymer model of chromatin organization influenced by Lamin proteins, showing how they shape chromosome territories and chromatin domain structures.

This paper introduces a low-cost cell preservation reagent inspired by natural mechanisms, showing it preserves mammalian cells for at least one week at 4°C or as dried samples.

The paper examines the cost of CpG-creating mutations in various human viruses using existing genomic data and finds they are generally costly.

This study investigates how a breast cancer GWAS variant may regulate immune cell gene expression in the tumor microenvironment, potentially affecting cancer progression.

This study uses molecular dynamics simulations to investigate how phosphorylation of PAGE4 affects its structure and interactions with AP-1 and AR, revealing conformational switching linked to prostate cancer progression.

This study shows that Id proteins suppress E2A-driven innate-like T cell development before TCR selection, promoting conventional T cell dominance.