S. Singh

This paper presents a method to improve kinase inhibitor selectivity by combining inhibitors with divergent off-target activities, validated using a NanoBRET assay.

The paper designs a chimeric peptide that inhibits Plasmodium falciparum red blood cell invasion with 100x higher efficacy than its parent peptides.

This study shows that stromal compartments in a mouse model of BPH are resistant to castration-induced regression, suggesting the need for additional therapies.

This study shows that a custom-designed PPR protein knocks down mitochondrial atp1 mRNA, reducing F1Fo ATP synthase, plant growth, and amino acid metabolism in Arabidopsis.

The paper examines antibody diversity in an unvaccinated SARS-CoV-2 infected individual, finding that post-vaccination neutralization breadth against Omicron variants is comparable to vaccinated individuals and breakthrough infections.

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

This study investigates why amyloid-β plaques in Alzheimer's Disease are visible in X-ray phase-contrast imaging, finding that metal entrapment, not fibrils, drives the contrast in transgenic rodents and human genetic cases.

This paper develops a size-tunable ICG-based contrast agent for NIR-PAI, showing enhanced in vivo imaging of liver and spleen with high photostability and targeting ability.

This study examines vascular function and blood pressure in a mouse model of Kawasaki disease, finding vascular dysfunction linked to COX-derived products, oxidants, and NO bioavailability.

This study evaluates Gepotidacin's activity against drug-resistant mycobacteria, showing potent in vitro and in vivo efficacy, resistance bypass, and synergistic potential.

The paper shows glucocorticoids enhance CD8+ T cell memory differentiation by promoting tissue-homing TRM cells and metabolic shifts via AMPK and STAT3/5 signaling.

This study investigates psilocybin's effect on marble-burying in mice, finding that 5-HT1A receptors mediate some effects but not the primary action, and that buspirone may block psychedelic effects without affecting anti-obsessional effects.

The paper profiles 218 cytotoxic and nuisance compounds in U-2 OS cells to create reference compounds for improving assay optimization and compound prioritization in cellular morphology assays.

This study evaluates novel CQTrICh-analogs as antimalarials, showing they inhibit Plasmodium falciparum strains and target PfCDPK1 kinase with selectivity over human kinases.

This study shows that TLR4 signaling in HIV-infected individuals enhances PD-L1 expression and modulates pDC function, contributing to immune suppression.

The paper analyzes water quality and fish diversity along the East Medinipur coast in West Bengal, finding correlations between water parameters and species richness across seasons.

This study shows that stabilizing PP2A with a small molecule enhances DNA damage-induced apoptosis in HGSC cells and xenografts, both alone and with PARPi, by inhibiting HR and targeting RAD51.

The paper identifies potential drug targets for intestinal fibrosis by combining image-based morphology analysis with AI and inflammatory biomarker measurements.

This study identifies Fbxo7's role in promoting Cdk6 activity to inhibit PFKP and glycolysis in T cells, revealing its impact on metabolism and viability.

This study identifies Niclosamide as a drug that disrupts Candida biofilms and develops nanoparticles to enhance its efficacy against drug-resistant strains.

The paper shows ABHD6 selectively regulates metabotropic-dependent 2-AG production via DAGL and calcium, unlike ionotropic-dependent increases.

This study shows that the Scar/WAVE complex can drive normal actin protrusions without the Arp2/3 complex and that proline-rich domains are essential for actin nucleation.

The paper shows LDL1 and LDL2 histone demethylases interact with FVE to repress floral repressors and regulate flowering in Arabidopsis.

This paper identifies small-molecule inhibitors of Plasmodium ClpQ protease that show anti-malarial activity against both blood and liver stages of malaria.

This study compares the response of three Brassica species to A. brassicae infection and exogenous phytohormones, finding that B. juncea is more susceptible due to SA-ABA synergy, while tolerant genotypes show JA-mediated resistance.

The paper identifies potent antimalarial compounds targeting PfTubulin that show multistage activity and transmission-blocking effects against Plasmodium falciparum.

The paper builds a model to predict gene expression from cell morphology in hiPSCs and identifies two genes well-predicted by morphology.

This study shows that Chikungunya virus (CHIKV) infection activates DNA damage response (DDR) pathways, increases DNA damage, and interacts with Chk2 and Chk1 to facilitate viral replication and cell cycle arrest.

This study identifies moxifloxacin-induced oxidative stress in Mycobacterium tuberculosis as a mechanism of killing, showing that reductive stress and iron contribute to ROS accumulation and drug efficacy.